Hello readers, below you will find an informative article to explain the benefits, uses, interactions, indications and side effects of Wintomylon. Get all the necessary information about this drug used to treat urinary tract infections and do not hesitate to share it on your favorite social networks, your followers will thank you.

What is Wintomylon?

Wintomylon is a treatment used for urinary tract infections caused by certain bacteria. It is an antibacterial and works by killing sensitive bacteria in the urinary tract and stopping the production of essential proteins that bacteria need to survive.

Indications of the Wintomylon

Wintomylon is indicated for the treatment of urinary tract infections caused by susceptible gram-negative microorganisms, which include most E. coli, Enterobacter species, Klebsiella species, and Proteus species. Susceptibility testing with the 30 mcg disc should be performed prior to drug administration and during treatment if the clinical response warrants.

To reduce the development of drug resistant bacteria and maintain the effectiveness of Wintomylon and other antibacterial drugs, Wintomylon should only be used to treat or prevent infections that have been shown or suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered when selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empirical selection of therapy.

How should Wintomylon be used?

Use Wintomylon as directed by your doctor. Check the medicine label for exact dosing instructions.

  • Take Wintomylon by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
  • Do not take products containing magnesium (eg, Quinapril, didanosine, vitamins), aluminum, calcium, sucralfate, iron, or zinc for 2 to 3 hours after taking Wintomylon suspension. These products bind with the medicine preventing its absorption.
  • Shake well before each use.
  • Use a marked measuring device for medication dosing. Ask your pharmacist for help if you are not sure how to measure your dose.
  • Drink a full glass of water with each dose. Drink several extra glasses of water daily, unless your doctor tells you otherwise. Do not take caffeinated products while taking Wintomylon.
  • To completely clear the infection, take Wintomylon for the entire treatment. Keep taking it even if you feel better in a few days.
  • If you miss a dose of Wintomylon, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at the same time.

Ask your healthcare provider any questions you may have about how to use Wintomylon.

Uses of Wintomylon

Wintomylon is used to treat urinary tract infections caused by certain bacteria.

Description of the Wintomylon

A synthetic 1,8-naphthyridine antimicrobial agent with a limited bactericidal spectrum. It is an inhibitor of bacterial DNA gyrase A subunit.

Recommended dose of Wintomylon

Antacids that contain calcium, magnesium, or aluminum; sucralfate; Divalent or trivalent cations such as iron; multivitamins containing zinc; o Videx® (Didanosine), pediatric powder chewable / buffered tablets for oral solution should not be taken within two hours before or within two hours after taking Wintomylon.

In adults: The recommended dose for initial therapy in adults is 1 g given four times a day for one to two weeks (total daily dose, 4 g). For prolonged therapy, the total daily dose can be reduced to 2 g after the initial treatment period. Underdosing during initial treatment may predispose to the development of bacterial resistance.

Pediatric patients: Until more experience is gained, Wintomylon should not be given to infants less than three months old. The dose in pediatric patients 12 years of age and younger should be calculated based on body weight. The recommended total daily dose for initial therapy is 25 mg / lb / day (55 mg / kg / day), administered in four equally divided doses. For prolonged therapy, the total daily dose can be reduced to 15 mg / lb / day (33 mg / kg / day). 250 mg Wintomylon Suspension or Wintomylon Caplets can be used. One 250 mg tablet is equivalent to one teaspoon (5 ml) of the suspension.

Contraindications of Wintomylon

Wintomylon is contraindicated in patients with known hypersensitivity to Wintomylon or related compounds, infants less than three months of age, and in patients with porphyria or a history of seizure disorders. Wintomylon is contraindicated in patients undergoing concomitant therapy with melphalan or other cancer-related chemotherapeutic alkylating agents due to severe gastrointestinal toxicity, such as ulcerative hemorrhagic colitis or intestinal necrosis.

Side effects of Wintomylon

Reported reactions after oral administration of Wintomylon include the following.

CNS Effects:

Drowsiness, weakness, headache, dizziness, and vertigo. Reversible subjective visual disturbances without objective findings have occurred infrequently (usually with each dose during the first days of treatment). These reactions include excessive brightness of lights, change in color perception, difficulty focusing, decreased visual acuity, and double vision. They usually disappeared quickly when the dose was lowered or treatment was stopped. Toxic psychosis or brief seizures have been reported rarely, usually after excessive doses. In general, seizures have occurred in patients with predisposing factors, such as epilepsy or cerebral arteriosclerosis. In infants and children who received therapeutic doses of Wintomylon, Increased intracranial pressure with bulging anterior fontanelle, papilledema, and headache has occasionally been observed. Some cases of sixth cranial nerve palsy have been reported. Although the mechanisms of these reactions are unknown, the signs and symptoms generally disappeared rapidly without sequelae when treatment was discontinued.

Gastrointestinal:

Abdominal pain, nausea, vomiting, and diarrhea.

Allergic:

Rash, pruritus, urticaria, angioedema, eosinophilia, arthralgia with joint stiffness and swelling, and anaphylactoid reaction, including anaphylactic shock. Erythema multiforme and Stevens-Johnson syndrome have been reported with Wintomylon and other drugs in this class. Rash was the most frequently reported adverse reaction. Photosensitivity reactions consisting of erythema and blisters on exposed skin surfaces generally resolve completely within 2 weeks to 2 months after Wintomylon is discontinued; however, blisters may continue to appear with successive exposure to sunlight or mild skin trauma for up to 3 months after drug discontinuation.

Other:

Rarely, cholestasis, paresthesia, metabolic acidosis, thrombocytopenia, leukopenia, or hemolytic anemia, sometimes associated with glucose 6-phosphate dehydrogenase deficiency and peripheral neuropathy.

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Dr. Samantha Robson ( CRN: 0510146-5) is a nutritionist and website content reviewer related to her area of ​​expertise. With a postgraduate degree in Nutrition from The University of Arizona, she is a specialist in Sports Nutrition from Oxford University and is also a member of the International Society of Sports Nutrition.

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