In the US, Vontrol (systemic diphenidol) is used to treat Meniere’s disease, nausea / vomiting, postoperative, and vertigo. Diphenidol is a muscarinic antagonist used as an antiemetic and as an antivertigo agent. It is not marketed in the United States or Canada. Although the mechanism of action of Diphenidol in the vestibular system has not yet been elucidated, it exerts an anticholinergic effect due to interactions with the mACh receptors, particularly M1, M2, M3 and M4.

Vontrol – Side Effects

Headache, upset stomach, dry mouth, blurred vision, changes in rest and sleep, and drowsiness are likely to occur in the first few days as your body adjusts to the medicine. If any of these effects continue or become bothersome, tell your doctor. Tell your doctor if you experience: hallucinations, confusion, disorientation, depression, rash, increased stimulation. This medicine may make you drowsy.

  • Confusion
  • Hallucinations (seeing, hearing, or feeling things that are not there)
  • Drowsiness (severe)
  • Difficulty breathing or trouble breathing
  • Unusual (severe) tiredness or weakness
  • Some side effects can occur that generally do not require medical attention.
  • Drowsiness
  • Blurry vision
  • Dizziness
  • Dry mouth
  • Headache
  • Acidity
  • Nervousness, restlessness, or trouble sleeping
  • Acne
  • Upset stomach or pain
  • Unusual tiredness or weakness

Other unlisted side effects can also occur in some patients.

Vontrol – Precautions

Tell your doctor about your medical history, especially of: kidney disease, ulcers, stomach or bowel disorders, prostate problems, glaucoma, heart disease, any allergies. This medicine should be used only if clearly necessary during pregnancy. Discuss the risks and benefits with your doctor. It is not known if this drug appears in breast milk.

It will combine the effects of alcohol and Central Nervous System depressants (medications that make you feel drowsy or less alert). Some examples of CNS depressants are antihistamines or medications for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleep medications; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while using diphenidol.

Diphenidol can cause some people to have blurred vision or dizziness, sleep, or less alert than normal. This is a decision that you and your doctor will make. For diphenidol, the following should be considered:


Advertise in case of allergies, such as foods, dyes, preservatives or animals. For non-prescription products, carefully read the label or package ingredients.


There is no specific information comparing the use of diphenidol for motion sickness in children with the use in other age groups. Also, there is no specific information on the use of diphenidol for nausea and vomiting in children weighing less than 22.8 kilograms (50 pounds).


Many medications have not been specifically studied in older people. So it may not be known if they work in exactly the same way as they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing the use of diphenidol in the elderly with the use in other age groups.

Vontrol – Utilities

Diphenidol is used to relieve or prevent nausea, vomiting, and dizziness caused by certain medical problems.

Vontrol – Interactions 

Although certain drugs should not be used together, in other cases two different drugs can be used even if an interaction occurs. In these cases, your doctor may want to change the dose, or other precautions may be necessary.

Certain medications should not be used at or near mealtime, as certain types of foods are eaten as interactions can occur. Using alcohol or tobacco with certain medications can also cause interactions. Talk to your healthcare professional about using your medicine with food, alcohol, or tobacco.

Other medical problems

The presence of other medical problems can affect the use of diphenidol. Be sure to tell your doctor if you have any other medical problems, especially:

  • Enlarged prostate or
  • Glaucoma or
  • Intestinal blockage or
  • Low blood pressure or
  • Stomach ulcer-Diphenidol can make these conditions worse.
  • Kidney disease or

Vontrol – Uses

If you are taking diphenidol to prevent nausea and vomiting, it can be taken with food. However, if you are already suffering from nausea and vomiting, it is best to keep an empty stomach, and diphenidol should be taken with only a small amount of water.

Take diphenidol only as directed. Do not take more and do not take it more often than directed by your doctor. Doing so can increase the chance of side effects.

Vontrol – Dosage

The diphenidol dose will be different for different patients. Be careful with the attention. Also, the number of doses you take each day, the time allowed between doses for which you are using the medicine.

For the oral dosage form (tablets):

Adults: 25 to 50 milligrams (mg) every four hours as needed.
Children: the dose is based on body weight and must be determined by the doctor.

Missed dose

If you miss a dose of diphenidol, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double dose

Vontrol – Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Avoid freezing.

Samantha Robson
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Dr. Samantha Robson ( CRN: 0510146-5) is a nutritionist and website content reviewer related to her area of ​​expertise. With a postgraduate degree in Nutrition from The University of Arizona, she is a specialist in Sports Nutrition from Oxford University and is also a member of the International Society of Sports Nutrition.

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