The trimebutine is an antispasmodic drug in a group of alkaloids. It is characterized by its anticholinergic and analgesic effects , which is why it is used to treat abdominal spasms , which are painful contractions in the smooth muscle tissue of this region, and which occur due to gastrointestinal problems.Trimebutine, being an anticholinergic, acts on the neurotransmitter acetylcholine , minimizing its activity in the peripheral and central nervous systems, reducing the reaction of muscarinic receptors. This is how it is possible to interrupt the contractions and spasms that occur in glands and organs.The functions of trimebutine address gastrointestinal conditions that involve spasms ; These include, for example, achalasia, ulcerative colitis, irritable bowel syndrome, and uncontrollable vomiting. It is effective for treating painful flatulence and constipation , both caused by intestinal hypomotility and intestinal hypermotility, and other problems.

What is trimebutine for?

Trimebutine, due to its antispasmodic, anticholinergic and analgesic effects, helps to calm the pain caused by various diseases , in which spasms in smooth muscle tissue are involved. These include colitis, diverticulitis, and irritable bowel.

Trimebutine is mainly used to:

  • Treat multiple diseases
  • Soothe pain in gastrointestinal conditions
  • Counteract irritable bowel and colitis
  • Reduce severe vomiting from various causes
  • Remedy constipation and intestinal dysfunctions

It is used to treat the following diseases:

Among the conditions and ailments that trimebutine can act on are:

  • Acalasia
  • Irritable bowel syndrome
  • Colitis
  • Diverticulitis
  • Ulcera duodenal
  • Hypomotility constipation
  • Constipation due to hypermotility
  • Pain in the large intestine
  • Gastritis
  • Vomiting from ulcers
  • Vomiting from spasms
  • Infant gastroenteritis
  • Abdominal distension
  • painful flatulence
  • Reflux
  • Ileo postquirurgo
  • Stomach cramps
  • Functional dyspepsia
  • Abdominal pain

Helps relieve pain in gastrointestinal conditions

Trimebutine is a drug that helps reduce gastrointestinal spasms.

Trimebutine is used mainly to treat gastrointestinal diseases and problems, thanks to the fact that it acts on the nervous plexuses of the intestines, called “Auerbach or Myenteric plexus” and “Meissner plexus”.

These nerve plexuses are responsible for the peristaltic movement , that is, the movement that the intestines make for digestion. In addition, they are dedicated to regulating colic, pain, the secretion of hydrochloric acid to digest food, the vomiting reflex and nausea.

Trimebutine does not completely interrupt intestinal motility, but rather moderates it, helping the digestive process to be more normal, while continuing to produce secretions, hormones and substances that are used in the digestive system.

Serves to counteract irritable bowel and colitis

Trimebutine helps control many of the symptoms related to irritable bowel syndrome, such as:

  • Inflammation
  • Abdominal pain
  • Feeling of being full
  • Irregularity in intestinal functions

It also helps, in colitis, to calm symptoms such as:

  • Abdominal pain
  • Diarrhea
  • Constipation
  • Inflammation
  • Gases
  • Urgency to defecate

In both diseases, trimebutine can be used as a complement to the patient’s medication, as there are specific medications for the primary causes, which can be bacterial, for example.

Reduce severe vomiting from various causes

Trimebutine has the function of inhibiting specific actions of the Auerbach and Meissner plexuses, thus reducing discomforts such as:

  • Vomiting reflex
  • Intestinal cramps
  • Abdominal pain from contractions
  • Pain in peristaltic movements

Therefore, the well-being of the patient is achieved in the first instance, to continue with the treatment that will mitigate the causative agent of the disease.

Remedy constipation and intestinal dysfunctions

Trimebutine helps eliminate colic from constipation.

Trimebutine helps regulate intestinal functions by correcting hypermotility and hypomotility of the intestines.

These conditions are described as:

  • Hypermotility: rapid or excessive bowel movement, during digestion of food.
  • Hypomotility: slow or poor bowel movement during digestion of food.

Trimebutine helps digestion to progress at a normal speed , so constipation and poor digestion disorders decrease.

It should be noted that trimebutine is not a laxative , but is limited to regularize peristaltic movements, to achieve proper digestion.

Contraindications of trimebutine

Trimebutine administration should be monitored by a medical professional, or avoided entirely in people such as:

  • Patients with allergies to this drug
  • Pregnant women; being an alkaloid it can affect the development of the baby
  • Lactating women
  • Elderly patients

Side effects of trimebutine

Trimebutine can have side effects such as:

  • Diarrhea
  • Dry mouth
  • Sickness
  • Confusion (more likely in the elderly)
  • Lightheadedness (more likely in the elderly)
  • Memory problems (more likely in the elderly)

This article is for informational purposes only and is not a substitute for professional medical opinion. Consult a doctor.



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