Terramycin is a bright yellow antibiotic that has a powerful antimicrobial activity, being more versatile, and it is powerful to fight infections caused by gram + and gram- bacteria, both aerobic and anaerobic, spirochetes, rickettsiae and some of the larger viruses .

Polymyxin B sulfate is part of a group of related antibiotics derived from Bacillus polymyxa. Polymyxins are rapidly bactericidal, this action is exclusively against gram-negative bacteria.

The broad spectrum effectiveness of Terramycin against gram-positive and gram-negative organisms is enhanced by the particular effectiveness of polymyxin B against infections associated with gram-negative organisms, especially those due to Pseudomonas aeruginosa, where polymyxin B is the antibiotic of choice. Additionally, there is evidence that polymyxin B sulfate possesses some antifungal activity.

The combined antibacterial effect of Terramycin plus polymyxin is at least additive and, in many cases, a real synergistic action is obtained. Terramycin is an ointment of oxytetracycline hydrochloride and polymyxin B sulfate in a special petrolatum base. Each gram of ointment contains oxytetracycline HCl equivalent to 5 mg of oxytetracycline and 10,000 units of polymyxin B as sulfate.

INDICATIONS AND USE: Terramycin is indicated for the prophylaxis and local treatment of ocular and superficial infections due to oxytetracycline and organisms sensitive to polymyxin, including infections due to streptococci, rickettsiae, E. coli and A. aerogenes, such as conjunctivitis, keratitis, pink eye, corneal ulcer, blepharitis in dogs, cats, cows, sheep and horses; eye infections, and bacterial inflammatory conditions that can occur secondary to other infectious diseases in the above species.

WARNING: Serious, life-threatening and hypersensitive (anaphylactic) reactions have been reported in some cats after application of antibiotic ophthalmic preparations.

If your cat develops a swollen face, itchiness, weak appearance, vomiting, or difficulty breathing within 4 hours of application, you should stop treatment and contact your veterinarian immediately.

Note: The use of oxytetracycline and other antibiotics can result in the overgrowth of resistant organisms such as Monilia, staphylococci, and other species of bacteria. If new infections appear due to insensitive bacteria or fungi during treatment, appropriate measures should be taken.

DOSE AND ROUTE OF ADMINISTRATION

Terramycin (oxytetracycline hydrochloride and polymyxin B sulfate ophthalmic ointment) should be administered topically to the eye 2 to 4 times a day.

RECOMMENDED STORAGE : Store at controlled room temperature between 20 ° and 25 ° C (68 ° to 77 ° F), with excursions between 15 ° and 30 ° C (59 ° to 86 ° F).

Oxytetracillin is a broad spectrum antibiotic effective against gram-positive and gram-negative bacterial infections. It is an isolated substance from the actinomycete Streptomyces rimosus being used in a variety of clinical conditions.

History

It was discovered by the Pfizer Laboratory in portions of soil that had the presence of the actinomycetes Streptomyces rimosus in a study conducted by Finlay et al. In 1953 biochemist Robert Burns Woodward studied the chemical structure of Oxytetracycline allowing Pfizer to produce the drug on a large scale under the trade name Terramycin. Woodward’s studies in the discovery of the chemical structure of oxytetracycline were important for the discovery of new derivative antibiotics such as Doxycycline, one of the most popular antibiotics today.

Indication

In the use of medicine oxytetracycline is used to fight diseases caused by bacteria sensitive to oxytetracycline. As well as other Tetracycline, being indicated to combat strange or known infections caused by bacteria. Due to its better absorption characteristics, it is preferable in relation to other tetracyclines to treat moderate and severe acne. Alternatives should be investigated if no results are obtained in 3 months.

It is sometimes useful for the treatment of spirochete and clostridial infections. It can be administered to treat Anthrax infections in patients sensitive to Penicillin. Oxytetracycline is used to treat respiratory diseases, urinary tract, skin, ears, eyes, and Gonorrhea, although the use of tetracyclines has been reduced to these diseases due to the resistance of these pathogens to this class of medicines. The drug is particularly useful when the patient is allergic to Penicillin and / or Macrolides. It can be used to treat Legionnaires’ Disease replacing the Macrolide or Quinolone antibiotics.

Oxytetracycline is good for treating unspecified urethritis, lymphogranuloma (LGV), lyme disease, brucellosis, cholera, plague, typhus, relapsing fever, tularemia, and infections caused by chlamydia, mycoplasma, and rickettsia. Doxycycline is currently preferable to oxytetracycline for most of these indications.

Veterinary use

In veterinary medicine, oxytetrathicin is used mainly in poultry and livestock farming. In poultry it is used to treat diseases caused by Mycoplasma gallisepticum (conical respiratory disease of birds), Mycoplasma synoviae, Escherichia coli, Salmonella spp, Haemophillus spp, Clostridium spp. Resistant strains are treated with a dosage increase, which is not the case with other commonly used antibiotics.

Looking to find if oxytetracycline can be incorporated into shrimp culture, scientists are working, with the aim of assigning benefits in the control of diseases caused by different bacteria such as Vibrio spp, Pseudomonas spp, Aeromonas spp, Rickettsia spp, Salmonella spp. , Pasteurella spp, Escherichia coli, Edwarsiella spp, Chilodoneila spp, Enibacterium pp, Proteus spp, Flexibacter spp (Cytophaga Chondrococcus), Yersinia spp. One of the concerns about the use of oxytetracycline in animals intended for slaughter or milk production (food production in general) is aimed at controlling the presence of this antibiotic in food intended for human consumption.

What is Terramycin indicated for?

• Rocky Mountain spotted fever, typhoid and typhoid fever, tick-borne fever, caused by Rickettsiae;
• Psoriasis caused by Chlamydia psittaci;
• Trachoma caused by Chlamydia trachomatis although the infectious agent is not always eliminated, as assessed by immunofluorescence;
• Conjunctivitis caused by Chlamydia trachomatis; it can be treated with oral tetracyclines or with a combination of topical and oral agents. It is of the inclusion type;
• Louse-borne relapsing fever caused by Borrelia recurrentis.

Terramycin is also indicated for the treatment of infections caused by the following gram-negative microorganisms:

• Bartonelosa caused by Bartonella bacilliformis;
• Bacteroides spp;
• Cholera caused by Vibrio cholerae (formerly Vibrio comma);
• Campylobacter fetus (formerly Vibrio fetus);

Terramycin is indicated for the treatment of infections caused by the following gram-positive microorganisms when bacteriological tests indicate appropriate susceptibility to the drug:

• Escherichia coli;
• Enterobacter aerogenes (formerly Aerobacter aerogenes);
• Shigella spp.;
• Acinetobacter spp. (formerly Mima spp. and Herellea spp.);
• Respiratory infections caused by Haemophilus influenzae;
• Respiratory and urinary tract infections caused by Klebsiella spp.

Terramycin is indicated for the treatment of infections caused by the following gram-positive microorganisms when bacteriological tests indicate adequate susceptibility to the drug:

Warnings in the use of Terramycin

In case of kidney failure, even the usual oral or parenteral doses can cause systemic accumulation in large proportions of the drug, which can lead to liver toxicity. In these circumstances, total doses smaller than the usual ones are indicated and, if the treatment is prolonged, it is advisable to determine the serum levels of the drug to avoid possible damage in the future.

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Dr. Samantha Robson ( CRN: 0510146-5) is a nutritionist and website content reviewer related to her area of ​​expertise. With a postgraduate degree in Nutrition from The University of Arizona, she is a specialist in Sports Nutrition from Oxford University and is also a member of the International Society of Sports Nutrition.

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