The pravastatin is a drug used to reduce levels of bad cholesterol or LDL (Low Density Lipoprotein) and triglycerides in patients with hypercholesterolemia, atherosclerosis and coronary disease. This medicine belongs to the group of statins , which are chemicals that are used to lower different types of cholesterol.Pravastatin is derived from the fungus Nocardia autotrophica , being a fungal metabolite isolated from this microorganism. The mechanism of action of this drug consists of inhibiting the enzyme HMGCR (3-hydroxy-3-methyl-glutaryl-CoA reductase), which is responsible for controlling the mevalonate pathway , a metabolic pathway that manufactures dimethylallyl pyrophosphate and pyrophosphate isopentyl.Both substances are necessary for the creation of terpenes , which in turn are substances involved in the formation of steroid hormones , blood and cholesterol , among others. Pravastatin, by inhibiting the HMGCR enzyme, ensures that the liver does not produce LDL cholesterol as quickly, while HDL cholesterol is increased, helping the arteries not to clog.

What is pravastatin for?

Pravastatin, by reducing the levels of LDL cholesterol (or bad cholesterol) in the blood and helping to produce HDL cholesterol (or good cholesterol, High Density Lipoprotein), helps reduce and control many diseases related to cholesterol levels, such as arteriosclerosis, coronary arteries, cerebral embolisms, diabetes and some complications from obesity.

It serves to:

  • Treat cholesterol-related diseases
  • Counteract hypercholesterolemia and other conditions
  • Prevent coronary heart disease
  • Avoid strokes

It is used to treat the following cholesterol-related diseases

Pravastatin is a drug that represents a great support for diseases and conditions such as:

  • Myocardial infarction
  • Coronary heart disease
  • Apoplexy
  • Arteriosclerosis (blockage of the arteries by bad cholesterol)
  • Mellitus diabetes
  • Hypercholesterolemia
  • Angina pectoris
  • Hyperlipidemia (excess lipids in the blood)
  • Hypertriglyceridaemia (excess triglycerides in the blood)
  • Cardiovascular diseases
  • ischemia
  • Strokes
  • Post-organ transplant recovery
  • Obesity

Helps counteract hypercholesterolemia and other conditions

Pravastatin works to lower bad cholesterol or LDL.

The main function of pravastatin is to reduce the levels of harmful fats and LDL cholesterol in the blood. By inhibiting enzymes related to the production of LDL cholesterol and assisting in the production of HDL cholesterol, it allows the arteries to improve their blood flow .

It is used in patients with hypercholesterolemia, or who have suffered heart attacks or have coronary artery disease, especially in patients over 40 years of age or whose cholesterol levels range from moderate to severe.

For this reason, it is a widely used drug for diseases such as obesity, arteriosclerosis and diabetes mellitus, even helping to prevent the latter, according to research.

It is used to prevent coronary heart disease

Pravastatin is one of the most used drugs to prevent and treat cholesterol-related cardiovascular diseases , as it helps to clear the heart walls, improves the endothelium and prevents the production of thrombi, which is why it is useful in patients who have already had heart attacks or angina pectoris and in those with a history of genetic predisposition.

Avoid strokes

The stroke, ischemia and stroke are associated with partial or complete blockage of arteries and vessels, thereby causing a loss of nutrients and oxygen in the tissues. This can lead to tissue cell death.

Pravastatin helps rid the arteries of cholesterol and improves the quality of their internal lining, the endothelium, thereby improving blood flow and oxygenation of damaged tissues.

Contraindications of pravastatin

Pravastatin works to prevent conditions such as arteriosclerosis.

Pravastatin administration should be under medical supervision or completely avoided in people such as:

  • Patients with severe liver disease
  • Patients with kidney failure
  • Patients with an allergy to pravastatin
  • Pregnant women
  • Lactating women

Side effects of pravastatin

In patients who do not have any of the above drawbacks, serious side effects are rare. In most cases, the side effects are mild and temporary, but it is always advisable to notify the doctor of any of them.

The most common side effects of pravastatin are:

  • Dizziness
  • Sickness
  • Flatulence
  • Headache
  • Pain in the abdomen
  • Diarrhea
  • Constipation

This article is informational in nature and is not a substitute for professional medical opinion. Consult a doctor.

Samantha Robson
 | Website

Dr. Samantha Robson ( CRN: 0510146-5) is a nutritionist and website content reviewer related to her area of ​​expertise. With a postgraduate degree in Nutrition from The University of Arizona, she is a specialist in Sports Nutrition from Oxford University and is also a member of the International Society of Sports Nutrition.

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