The Metamizol is an antispasmodic drug , analgesic , antiinflammatory and antipyretic nonsteroidal. Its effect is very powerful and is used in cases of severe pain and fever. For example, it is administered to relieve post-surgical pain, tumor pain, pain from severe trauma and chronic diseases such as cancer.Being a strong antipyretic and anti-inflammatory, it is often applied when other fever-reducing medications do not work or when rapid fever control is required. The mechanism of action of metamizole, like that of other pyrazolones, consists in the inhibition of prostaglandin synthesis . This reduces inflammation, fever and pain.Metamizole was discovered in the early 1920s, as a result of the synthesis of sodium sulfonate from amidopyrine , but it was in the 1970s that it was restricted, and its use was even banned in various countries, as this drug may cause Neutropenia, a serious illness.

What is metamizole sodium for?

Being an antispasmodic, analgesic, anti-inflammatory and antipyretic drug, metamizole serves to calm painful muscle contractions, severe pain, inflammation and fever in specific cases, where other medications do not respond or a rapid chemical action is required against symptoms.

Metamizole sodium is used to:

  • Soothe symptoms and severe pain
  • Treat acute or chronic pain
  • Control fever
  • Reduce colic

Soothe symptoms and severe pain

Among other symptoms and diseases, metamizole sodium is involved in the treatment of:

  • Intense pain
  • Post traumatic pain
  • Surgical pain
  • Glaucoma pain
  • Tumor pain
  • Intense headache
  • Burn pain
  • Gout pain
  • Intestinal cramps
  • Biliary colic
  • Kidney colic
  • Menstrual cramps
  • Refractory fever
  • Herpes zoster
  • Trigeminal neuralgia
  • Neuritis

Treat acute or chronic pain

Metamizole sodium is a widely used drug for reducing fever and spasm discomfort.

Metamizole acts on the spinal cord and nervous system , inhibiting pain signals . It is used to treat trigeminal neuralgia, neuritis, pain from tumors, and acute or chronic pain, in which the patient does not respond to other analgesics.

This drug is administered in cases of trauma, surgeries and illnesses with the presence of severe pain, such as the aforementioned, gout and cancer.

Control fever

One of the most common uses of metamizole sodium is as an antipyretic, that is, to reduce fever. It is applied in cases of refractory fever , where it is not possible to control body temperature physically or with other medications.

Reduce colic

Most severe colic responds to metamizole, as it inhibits spasms in the smooth muscles , thereby reducing pain caused by contractions of the affected organs.

Stomach, biliary, kidney and uterine colic are significantly reduced with this drug, which has the advantage of being gentle on the stomach and not causing bleeding or the dangerous effects that other non-steroidal anti-inflammatory drugs have on the digestive system.

Presentations of metamizole sodium

Metamizole, as a drug, is useful as a sodium salt and as a magnesium salt. However, the most common active ingredient is sodium salts .

The presentation of this medicine can be:

  • Pediatric suspension
  • 500mg tablets
  • Injectable solution for intravenous administration, when it is not possible to administer it otherwise.

Contraindications of metamizole sodium

Metamizole sodium can cause agranulocytosis if its use is not monitored.

This medicine should be avoided in people like:

  • Pregnant women
  • Babies and children in early infancy
  • Patients with an allergy to pyrazolones

Side effects of metamizole sodium

Currently, this drug has restrictions in some countries, because although it does not have as many side effects, some of them are potentially dangerous or even fatal.

The agranulocytosis and aplastic anemia are the two most important side effects that may occur to taking metamizol, and for these reasons is that in many places the drug can only be acquired by presenting a prescription.

Although the rate of patients with agranulocytosis or aplastic anemia is really low, the severity of these diseases and other considerable side effects have led to their restriction, and in some countries, their prohibition.

It is essential to see a doctor if any adverse reaction to metamizole occurs, as mild symptoms can evolve into serious or fatal conditions.

Some side effects of metamizole sodium are:

  • Allergy
  • Asthma
  • Itching
  • Swelling
  • Digestive disorders
  • Anaphylactic shock
  • Rubefacción
  • Angioedema
  • Aplastic anemia
  • Pancytopenia
  • Leucopenia
  • Stevens-Johnson syndrome
  • Thrombocytopenia
  • Agranulocitosis

The agranulocytosis or neutropenia is undoubtedly one of the most serious side effects, it destroys neutrophils , a type of white blood cells that protect the body against pagótenos. That is why when their number decreases, the immune system is unable to defend itself against infections.

Agranulocytosis is life threatening, therefore medical monitoring is necessary when taking metamizole and any other pain reliever in the pyrazolone family.

The aplastic anemia is a disease in which cell lines from bone marrow exhibit defective growth, which lowers the level of erythrocytes condition that leads to a difficult anemia address, and can endanger life, especially if a strong infection develops.

WATCH OUT! It is advised to avoid self-medication with this drug.

This article is informational in nature and does not substitute for professional medical opinion. Consult a doctor.

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