The imipramine is an antidepressant drug in a group of dibenzazepines , which are derived substances dibenzazepine, a tranquilizer composed of two rings attached benzene to azepines, which acts on the serotonin receptors , the most important neurotransmitter regulation of mood.Imipramine belongs to the family of drugs called tricyclic antidepressants , which are distinguished by having three benzene rings (C 6 H 5 -). Its mechanism of action consists of intervening the serotonin, norepinephrine and other neurotransmitter receptors, preventing them from being reuptained by the neuronal membrane.

In this way, these neurotransmitters remain available for use by the central nervous system. Imipramine has anticholinergic effects , that is, it acts on acetylcholine, a neurotransmitter responsible for regulating functions of the parasympathetic system, metabolism, digestion, peristalsis (bowel movement), urination and heart rate.

What is imipramine for?

Being an antidepressant and reliever, imipramine serves to help patients with depression control and improve their mood . Thanks to its anticholinergic effects, it also helps control emotionally rooted problems, such as infant enuresis (when children wet the bed at night), night terror, panic attacks and panic attacks.

Imipramine has been used since the 1960s as a treatment for all types of depression , although its use is currently more limited due to the discovery of more effective treatments and the side effects of this drug.

It serves to:

  • Treat emotional problems and their derivatives
  • Treat depression, melancholy, and anxiety
  • Treat bed-wetting and incontinence
  • Treat night terrors, distress, and behavioral disorders

Treat emotional problems and their derivatives

Imipramine is useful to counteract conditions that have an emotional and psychological root. In addition, it can help to treat the symptoms that derive from them. Among the problems that imipramine may be involved in are:

  • Depression
  • Neurotic depression
  • Melancholia
  • Attention deficit (only specific cases)
  • Anxiety
  • Chronic pain syndrome
  • Anguish crisis
  • Infant enuresis (when children urinate in the bed at night)
  • Depressive syndromes
  • Night terrors
  • Pictures of hysteria
  • Hipocondriasis
  • Concentration problems (only specific cases)
  • Stress incontinence
  • Urinary incontinence (only specific cases)
  • Panic attack heartbeat
  • Dry mouth from panic attack
  • Sweats from anxiety and panic
  • Intestinal disorders due to anxiety and panic

Imipramine can treat cases of depression and anxiety.

Treat depression, melancholy, and anxiety

The most recognized and appropriate use of imipramine is as an antidepressant for all cases of depression, as it has a wide range of activity. It is used to treat different types of depression, such as:

  • Neurotic depression
  • Psychotic depression
  • Depression and myotonic dystrophy
  • Endogenous depression
  • Exogenous depression

Imipramine is used as the main medicine or as part of drug therapy, depending on the type of depression or behavior disorder of the patient.

Imipramine, being a tranquilizer, is used to control panic attacks and attacks of hysteria .

Treat bed-wetting and incontinence

Bedwetting, a term that means “urinating at night,” can occur during two stages of life: in childhood, around 5 years of age, or in old age . It is at these ages that you do not have good toilet training. This phenomenon consists of the individual realizing that he has urinated the bed while sleeping, without having been able to contain it.

Imipramine is the most prescribed medication to help children over 5 years of age avoid enuresis, as it effectively reduces symptoms and improves urination control . This drug is used in conjunction with psychological therapies to support children in the process of dealing with and overcoming this problem.

Imipramine is also used in specific cases of incontinence , because although its mechanism of action on sphincter control is not fully known, it is known that its anticholinergic properties intervene in better control of urination. Reduces bladder contractility, while increasing resistance to bladder emptying.

This drug is usually administered with other anticholinergics and complementary medications.

Treat night terrors, distress, and behavioral disorders

Imipramine helps calm people who are going through a panic attack. Anguish attacks or panic disorders are characterized by causing intense fear or terror in a few minutes.

This fear or terror usually appears accompanied by several physical symptoms, mainly:

  • Strong palpitations
  • Sweating
  • Suffocation
  • Sickness
  • Dizziness
  • Fainting
  • Shaking chills
  • Tremors

These panic attacks may not be related to events that, as such, are causing fear . They even manifest themselves in moments of calm. Imipramine helps control symptoms and also reduces anxiety and depression. Its administration is usually strictly supervised by a doctor, due to its side effects.

Night terrors are soil disorders caused by overactivation of the central nervous system. This excessive activation occurs while children sleep, and it is due to the fact that children’s nervous systems are still developing.

This causes terrors or fears, accompanied by:

  • Screams
  • Sweating
  • Palpitations
  • Crying

They are similar to nightmares but, as they occur between stages of sleep, there are no images or memories of what caused the terror. Imipramine is used in conjunction with therapy and a change in habits, such as playing a sport, to reduce this problem.

Contraindications of imipramine

Imipramine should be administered under medical supervision or completely avoided in cases of people such as:

  • Pregnant women
  • Lactating women
  • Minors

Side effects of imipramine

Imipramine does have side effects. As it is a tricyclic antidepressant with anticholinergic properties, it can cause adverse, potentially harmful symptoms. For this reason, this drug is usually only prescribed after a good assessment of the risk-benefit ratio, and is used only in specific cases.

Some of the side effects of imipramine are:

  • Fatigue
  • Drowsiness
  • Delirium
  • Hallucinations
  • Increase in suicidal tendencies
  • Aggressiveness
  • Dry mouth
  • Sweating
  • Changes in urination
  • Tachycardia
  • Sickness
  • Threw up
  • Gastrointestinal disorders
  • Urticaria
  • Weight gain
  • Changes in libido

These symptoms vary from patient to patient, and therefore may not appear. It is important that any of these symptoms be reported to the doctor immediately.

Sometimes stopping the drug produces other symptoms, especially gastrointestinal disorders; For this reason, it is advisable to ask your health professional for instructions.

This article is for informational purposes only and is not a substitute for professional medical opinion. Consult a doctorIt may interest you:


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