The Hydroxyzine is a medication that belongs to the family of diphenylpiperazines. Its main effects are as an antihistamine (combats allergy symptoms), antiemetic (stops vomiting) and anxiolytic (reduces anxiety episodes). It can be included as a medication prior to anesthesia and as a mild pain reliever after an operation.echanism of action is estimated to be by suppressing activity in key regions of the subcortical area of ​​the central nervous system. Hydroxyzine has been shown to cause relaxation in skeletal muscle, dilation of the bronchi, decreased symptoms of allergies, suppression of vomiting, and mild analgesic effects.

What is hydroxyzine for?

Hydroxyzine is a drug with numerous applications thanks to its properties as an antihistamine, antiemetic, anxiolytic and mild anesthetic.

Hydroxyzine is used to:

  • Treat allergic reactions
  • Antispasmodic effects
  • Reduce vomiting
  • Treat anxiety episodes

Treat allergic reactions

Hydroxyzine is a histamine antagonist that acts at the H1 receptor level. It suppresses a portion of the smooth muscle responses to histamine , and is effective in preventing increased capillary permeability, edema formation, and pruritus that occur in immediate hypersensitivity reactions.

Between 15 and 60 minutes after hydroxyzine is administered orally, the antiallergic effect appears. Lasts from 4 to 6 hours. Although responses to histamine are suppressed, the release of this substance is not inhibited. Hydroxyzine does not attack antibody production or inhibit the reaction of antibodies with antigens.

Hydroxyzine is used to treat allergic reactions such as:

  • Itching
  • Allergic rhinitis
  • Rinitis vasomotora
  • Nasal bleeding or runny nose
  • Allergic conjunctivitis

Antispasmodic effects

Hydroxyzine is effective in preventing painful , involuntary muscle contractions , called spasms . This is attributed to its anticholinergic, antihistamine, and antiserotonin capabilities. It relaxes the smooth muscle when it has the impulse to contract, and eliminates the painful sensation that these contractions carry.

Reduce vomiting

Hydroxyzine is responsible for controlling the vomiting reflex. This drug has the advantage that it does not increase heartburn or gastric secretion. In addition, it produces in almost all cases a beneficial antisecretory effect.

This helps the stomach stay at a stable pH. The vomiting reflex causes the stomach muscle to contract to expel unwanted material from within, which normally causes stomach acids to come into contact with the esophagus. Hydroxyzine prevents this contact.

Treat anxiety episodes

Hydroxyzine is used to treat episodes of anxiety, which carry symptoms such as: pressure in the chest, shortness of breath, excessive worry and even irrational fears. This drug has sedative effects that will help calm all these symptoms.

Recommended dose of hydroxyzine

The dose of hydroxyzine to be administered will depend on the purpose you want to give it:

As an antihistamine , to treat itching due to allergic diseases such as urticaria and atopic dermatosis, the doses are:

  • In adults, 25mg of hydroxyzine, three or four times a day.
  • In children older than 6 years, between 50mg and 100mg of hydroxyzine per day, divided into several doses.
  • In children under 6 years of age, 50mg of hydroxyzine per day, divided into several doses.

As an anxiolytic , to relieve anxiety and tension due to psychoneurosis, the doses are:

  • In adults, between 50mg and 100mg of hydroxyzine, four times a day.
  • In children older than 6 years, between 50mg and 100mg of hydroxyzine per day, divided into several doses.
  • In children under 6 years of age, 50mg of hydroxyzine per day, divided into several doses.

As a sedative , for the premedication of a general anesthesia, the doses are:

  • In adults, between 50mg and 100mg of hydroxyzine, intramuscularly or orally.
  • In children, 0.6mg of hydroxyzine for each kilogram of the patient’s weight, intramuscularly or orally.

Hydroxyzine works to calm episodes of anxiety

Contraindications of hydroxyzine

Hydroxyzine is a drug whose administration should be controlled or avoided in people such as:

  • Patients with hypersensitivity to hydroxyzine
  • Patients who are taking nervous system depressants
  • Patients who are going to drive or operate dangerous machinery
  • Patients who have consumed alcoholic beverages
  • Pregnant women
  • Lactating women
  • Minors
  • Elderly patients

Hydroxyzine Side Effects

Hydroxyzine can have adverse effects, which are usually mild and temporary. Among them are:

  • Pustulosis exantematosa
  • Drowsiness
  • Dry mouth
  • Tremors (rare cases)
  • Seizures (rare cases)
  • Allergic reaction
  • Headache
  • Hallucinations
  • Urticaria
  • Rashes
  • Itching

This article is for informational purposes only and is not a substitute for professional medical opinion. Consult a doctor.

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Dr. Samantha Robson ( CRN: 0510146-5) is a nutritionist and website content reviewer related to her area of ​​expertise. With a postgraduate degree in Nutrition from The University of Arizona, she is a specialist in Sports Nutrition from Oxford University and is also a member of the International Society of Sports Nutrition.

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