The fexofenadine is an antiallergic drug indicated for the relief of symptoms associated with chronic idiopathic urticaria. Its mechanism of action consists of inhibiting the binding of histamine to its receptor, preventing it from acting. The histamine is a substance that releases the body at the entrance of a foreign substance. It’s a defense mechanism.
Histamine is the cause of itching, sneezing, watery eyes, inflammation of the nose or blockage, and some asthmatic processes. The fexofenadine is used primarily to treat these symptoms in seasonal allergic rhinitis. Its function is to remove discomfort so that the symptoms do not affect our daily activities.

What is fexofenadine for?

Fexofenadine is marketed and consumed as fexofenadine hydrochloride , and is a non-sedating antihistamine. It is a pharmacologically active metabolite of terfenadine. Studies of histamine wheals and skin erythema after 1 or 2-fold administration of fexofenadine showed that this drug begins to act after 1 hour .

The antihistamine effect peaks after 6 hours and lasts for 24 hours. No evidence of tolerance to these effects has been observed after 28 days of administration. The existence of a positive relationship between dose and response has been found in doses of 10mg to 130mg orally.

Fexofenadine has an antihistamine activity that requires doses of at least 130mg to achieve a firm effect that is sustained for a period of 24 hours.

Recommended dose of fexofenadine

Fexofenadine can be administered according to the age and health situation of the patient:

  • Adults and children over 12 years: 120-180 mg every 24 hours.
  • Children under 12 years of age: Safety and efficacy in these have not been established.
  • Elderly or patients with hepatic impairment: the dose is the same as in adult patients, 120-180 mg every 24 hours. There is no need to modify it.
  • Patients with moderate or severe renal insufficiency: an initial dose of 60 mg every 24 hours is recommended, adjusting the mg according to the organic response.

It should not be taken on an empty stomach. The tablets must be swallowed with a sufficient amount of liquid, a glass of water, for example. The duration of the treatment will be established by the doctor.

Contraindications of fexofenadine

The administration of fexofenadine should be monitored by the doctor in patients such as:

  • Allergic to fexofenadine
  • Allergic to terfenadine
  • Elderly patients
  • Patients with kidney disorders
  • Patients with liver disorders
  • Pregnant women
  • Lactating women

Side effects of fexofenadine

Possible side effects of fexofenadine are as follows:

  • Headache
  • Drowsiness
  • Dizziness
  • Fatigue
  • Sickness
  • Dyspepsia (difficult digestion)
  • Dysmenorrhea (altered menstruation)
  • Flu or other viral infections

This article is for informational purposes only and is not a substitute for professional medical opinion. Consult a doctor.


Samantha Robson
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Dr. Samantha Robson ( CRN: 0510146-5) is a nutritionist and website content reviewer related to her area of ​​expertise. With a postgraduate degree in Nutrition from The University of Arizona, she is a specialist in Sports Nutrition from Oxford University and is also a member of the International Society of Sports Nutrition.

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