The Dolo-Neurobion is a drug used to combat pain and inflammation . It is the trade name by which the mixture of diclofenac with B complex vitamins is known . It is an analgesic with properties against neuralgia, muscle aches and neuropathic pain in diabetic people.This drug was created by the German Merk laboratories , and is distributed in various countries around the world. It is a pioneer as it is the first commercial preparation. However, there are currently other generic and patent medicines with similar formulations.

Dolo-neurobion has a wide variety of uses, as it helps to calm pain , reduce inflammation , improve the quality of myelin , repair nerve endings to a certain degree and, in general, improve quality of life. of people with chronic pain, neuropathic pain and disorders related to the nervous system.

The Dolo neurobion serves to:

  • Treat diseases in general
  • Treat neuropathies, neuralgia, and fibromyalgia
  • Treat ankylosing spondylitis and carpal tunnel
  • Treat chronic arthritis, rheumatism, and joint pain

Treat diseases in general

Dolo-neurobion has a double effect: on the one hand, diclofenac controls pain and reduces inflammation, and on the other, the B-complex helps protect the myelin sheath and prevents it from being lost further.

Being an analgesic and non-steroidal anti-inflammatory drug (NSAID), and also having a B complex, Dolo-neurobion has several uses in medicine, mainly as a therapy against neuropathic pain, both neuropathies caused by diabetes and those caused by alcoholism. by syndromes and by other strong pains.

Some of the diseases that Dolo-neurobion is used for are:

  • Diabetic neuropathy
  • Alcoholic neuropathy
  • Peripheral neuropathy
  • Neuralgia herpética
  • Neuralgia intercostal
  • Neuralgia facial
  • Trigeminal neuralgia
  • ankylosing spondylitis
  • Fibromyalgia
  • Carpal tunnel syndrome
  • Chronic arthritis
  • Osteoarthritis
  • Spondylarthrosis
  • extra-articular rheumatism
  • Low back pain
  • Radiculitis
  • Acute gout
  • Chronic pain
  • Nerve injuries
  • Some burns
  • Beriberi symptoms
  • Painful tingling

Dolo-Neurobión is a mixture of drugs against pain and inflammation.

Treat neuropathies, neuralgia, and fibromyalgia

Dolo-neurobion, as a B-complex analgesic medicine , helps to a certain extent to reduce the discomfort caused by neuropathies, neuralgia and fibromyalgia. Some B-complex vitamins like B12 (cyanocobalamin) have been shown to help improve nerve functions by creating myelin that protects nerves.

In the same way, the central nervous system is kept healthy . This vitamin is essential, above all, in patients with peripheral neuropathy, which is produced among other things by the deficiency of vitamin B12.

Vitamin B1 (thiamine) contributes to the synthesis of acetylcholine, which is a neurotransmitter necessary for the transmission of nerve impulses through the peripheral nerves. In addition, this vitamin is involved in the synthesis of myelin which, as we have already said, is the protective and insulating sheath of the nerves.

Vitamin B6 (pyridoxine) is necessary for the metabolism of several neurotransmitters , especially those related to mood ; therefore, its deficiency is related to depression.

This vitamin also acts on other neurotransmitters and hormones; It is necessary for the formation of red blood cells and antibodies , and also for the regulation of insulin . Like vitamin B1, B12, B6 is necessary for the creation and maintenance of myelin.

Treat ankylosing spondylitis and carpal tunnel

Ankylosing spondylitis is a form of chronic arthritis that affects the spine producing, among other symptoms, inflammation and pain; therefore, diclofenac helps reduce discomfort. On the other hand, the B complex helps to maintain the central nervous system and reestablish the myelin sheath.

Dolo-neurobion is also used to reduce the discomfort and pain caused by carpal tunnel syndrome , since vitamin B6 has been used to treat inflammation, increase tolerance to pain and help reduce the neuropathy that causes this disease. .

Vitamin B12 is used for trigeminal neuralgia, as this vitamin has antineuralgic properties, complementing those of diclofenac on pain and inflammation.

Treat chronic arthritis, rheumatism, and joint pain

Dolo-neurobion contains diclofenac, which is a non-steroidal analgesic with effects on rheumatic and arthritic pain , also reducing joint inflammation. On the other hand, the B complex that this drug contains helps the nerves to be more protected and helps them, the joints and the tissues to be healthier.

Recommended dose of Dolo-neurobion

The dose to be administered of Dolo-neurobion will depend on the presentation, either as an injectable solution or tablets.

The injectable solution comes in two vials:

  • Ampule 1: 100mg of vitamin B1, 100mg of vitamin B6, 1 microgram of vitamin B12. It has a volume of 1 ml.
  • Ampoule 2: 75mg of diclofenac. It has a volume of 2ml.

Both vials are mixed in a single syringe and given as a muscle injection, once a day . The duration of the treatment will be determined by the doctor, depending on the case.

The lozenges contain 50mg of diclofenac, 50mg of vitamin B1, 50mg of vitamin B6 and 1mg of vitamin B12. Each tablet is swallowed after each meal . They can be two to three of them . This will be determined by the doctor.

How does Dolo neurobion work?

The mechanism of action of Dolo-neurobion consists of the combination of diclofenac with vitamin B1 (thiamine), vitamin B6 (pyridoxine) and vitamin B12 (cyanocobalamin), which are necessary for the protection and maintenance of myelin, which is the structure that covers the axons of the nerves .

When myelin is damaged by diseases, by certain accidents or by the action of certain chemical reagents, nervous disorders occur, the main one being neuropathic pain or neuropathy. The combination of diclofenac with B complex helps reduce pain and discomfort related to the loss of myelin .

Contraindications of Dolo-neurobion

The consumption of Dolo-neurobion should be under medical supervision or completely avoided in people such as:

  • Pregnant women
  • Minors
  • Patients allergic to any of the components of the formula
  • Elderly patients

Since it is not a multivitamin or a substitute for other sources of B-complex vitamins, there should be precautions when dosing.

Dolo-neurobion side effects

Like any other medicine, Dolo-neurobion can cause side effects if taken without the proper precautions. This medicine contains diclofenac , which is a non-steroidal pain reliever (NSAID) and, like the other pain relievers in this category, causes gastrointestinal upset, which can be more severe in some people.

The side effects that it can produce are:

  • Gastrointestinal upset
  • Stomach bleeding
  • Gastric ulcer
  • Kidney damage
  • Hepatic injury

Dolo-neurobion also contains B complex which, although it is a water-soluble vitamin and the surplus is discharged through the urine, it can also cause side effects when it is consumed in excess or there is no need to use it, since the daily diet contains enough.

However, in some cases, the B complex is related to an increase in acne , which usually disappears when excessive consumption is stopped.

This article is for informational purposes only and is not a substitute for professional medical opinion. Consult a doctor.


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Dr. Samantha Robson ( CRN: 0510146-5) is a nutritionist and website content reviewer related to her area of ​​expertise. With a postgraduate degree in Nutrition from The University of Arizona, she is a specialist in Sports Nutrition from Oxford University and is also a member of the International Society of Sports Nutrition.

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