The chlorthalidone is a drug used thiazide diuretic and antihypertensive . It is used as a treatment for edema, hypertension and cases of fluid retention in the heart, kidney and liver organs.This drug is used as a therapy against diseases that cause fluid accumulation . It is responsible for purging the excess of these through the urinary system. Sometimes it is accompanied with nitroglycerin and other antihypertensive drugs, and in others it is administered alone.As a diuretic, the mechanism of action of chlorthalidone consists in acting on the tubular transport mechanism of the kidneys , intervening in the thiazine receptors of this system. This prevents chlorine and sodium from being reabsorbed, in addition to promoting potassium excretion and minimizing calcium absorption, which is why kidney stones are also treated.

What is chlorthalidone for?

Chlorthalidone’s main pharmacological functions help in cases of hypertension and reduce fluid retention in the heart, kidney and liver areas. Due to this diuretic action, it is also used in cases of trauma edema, and as a complement in the treatment of premenstrual syndrome.

Chlorthalidone is used to:

  • Treat specific conditions
  • Treat hypertension
  • Diuretic effects
  • Treat edema
  • Control premenstrual syndrome

Treat specific conditions

Chlorthalidone is a suitable drug for the treatment of conditions involving the circulatory system, the urinary system, and the liver.

Among them are:

  • Estasis sanguínea
  • Arterial hypertension
  • Edema from trauma
  • Edema caused by venous insufficiency
  • Left ventricular hypertrophy
  • premenstrual syndrome
  • Prophylactic in cases of kidney stones
  • Hypoparathyroidism (deficiency disease of the parathyroid glands)
  • Liver cirrhosis due to ascites
  • Ménière’s disease
  • Decreases polyuria (excessive urination) in nephrogenic diabetes insipidus
  • Nephrolithiasis (kidney stones)
  • Dent disease
  • Hypertensive myocardial infarctions
  • Congestive heart failure
  • Chronic renal failure

Treat hypertension

Chlorthalidone is an effective drug for regulating blood pressure.

Hypertension is the elevation of the pressure with which the blood circulates through the arteries. This excess represents a risk for the cardiac tissue, which will make an effort to adjust to that flow rate.

Chlorthalidone helps reduce up to 12.0 / 4 mmHg, the pressure of systole and diastole (cardiac contraction and expansion), resulting in a regulation of intracellular fluid and plasma. Cardiac output stabilizes and vascular resistance is reduced, resulting in a decrease in hypertension.

Diuretic effects

By promoting the excretion of sodium, chlorine and water , through the intervention of chlorthalidone in the epithelium of the renal tubular mechanism, fluids with salts from the body are more easily drained through the urine. This drug is involved in the treatment of conditions that cause fluid retention , in organs such as the heart, kidneys and liver.

Treat edema

Chlorthalidone is widely used in cases of localized edema, such as:

  • Edema due to nephrotic syndrome
  • Cardiac edema
  • Hepatic edema
  • Edema from trauma
  • Edema from surgeries

Its use in the treatment of lymphedema will depend on the degree of progression of the disease and its primary cause, since this determines the effectiveness of chlorthalidone.

Control premenstrual syndrome

Chlorthalidone is used as part of the treatment of PMS, only when the main symptom is fluid retention or inflammation, accompanying colic and normal bleeding.

Contraindications of chlorthalidone

This drug is one of the most widely used as antihypertensives, especially in elderly and elderly patients. There is no evidence of its action in children, since hypertension is a more characteristic disease of advanced age.

This drug should be avoided or administered with medical supervision in people such as:

  • Pregnant and lactating women
  • Patients allergic to sulfonamides (organic sulfur chemicals)
  • Patients with kidney failure
  • Patients with liver failure
  • Diabetic patients receiving hypoglycemic drugs or insulin
  • Patients with difficulty urinating (dysuria)
  • Patients with prolonged absence of urination (anuria)
  • Hypocalcemic patients
  • Patients with hypercalcemia
  • Patients with lupus erythematosus
  • Patients with hyperuricemia
  • Gout patients

Before any of these diseases or conditions, it is necessary to inform the doctor, as chlorthalidone can make them worse or react with the chemical substances that are administered simultaneously. It is only used under medical supervision.

Chlorthalidone Side Effects

It is necessary to monitor blood pressure in hypertensive patients, when administering chlorthalidone.

Clotalidone can cause side effects if its consumption is excessive or combined with inappropriate substances. You should go to the emergency room if you have any of these symptoms:

  • Anaphylactic shock
  • Asthma
  • Swelling
  • Urticaria
  • Rash
  • Dark urine
  • Dry mouth
  • Tingle
  • Sickness
  • Threw up
  • Diarrhea
  • Constipation
  • Loss of consciousness
  • Swelling in the throat

This article is for informational purposes only, and is not a substitute for professional medical opinion. Consult a doctor.

Samantha Robson
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Dr. Samantha Robson ( CRN: 0510146-5) is a nutritionist and website content reviewer related to her area of ​​expertise. With a postgraduate degree in Nutrition from The University of Arizona, she is a specialist in Sports Nutrition from Oxford University and is also a member of the International Society of Sports Nutrition.

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