Uromycin is a drug that plays a very important role as the active element that serves to combat a wide range of urinary tract infections caused by different types of germs and bacteria. It is widely used for its efficacy and low rate of adverse effects. Due to these characteristics, it is considered a good alternative for the treatment of people with sensitivities to other drugs.
What is uromycin
Uromycin is a medicine that is marketed in capsule form and is composed of the following active ingredients: 250 mg sulfamethizole, 125 mg tetracycline HCI, and 50 mg phenazopyridine.
Both sulfamethizole and tetracycline HCI have antibiotic action, while phenazopyridine is recognized for its analgesic and anti-inflammatory properties, especially at the urinary system level.
Therefore, uromycin is a drug that has antibiotic, anti-inflammatory and analgesic properties recommended to combat infections related to the urinary tract and their possible complications.
What is uromycin for
Due to its components, which act as antibiotics and analgesics, uromycin is used in the treatment of infections that affect the urinary system; to relieve pain, burning, irritation and discomfort in the urinary tract, as well as the various complications that can arise from infections that occur in the urinary tract.
Uromycin is useful for complications of dysuria
Dysuria is the medical name for painful urination, which is a symptom of a urinary tract infection. However, dysuria is also an indicator of the presence of some sexually transmitted disease, kidney stones, tumors and other conditions of the prostate.
Due to its antibiotic action, uromycin works by cutting off the infection process, relying on its analgesic action to alleviate the annoying symptoms of this process.
Uromycin is used for urogenital infections
As a consequence of infections in the organs and pathways associated with urine, urinary emergencies such as urinary incontinence and frequent nocturnal urination may occur.
When uromycin treatment ends the infection, these alternate complications also disappear. If the symptoms continue, it is recommended that the patient go to the urologist’s office.
Uromycin is used to treat urgency
Urinary urgency is the false feeling of the need to empty the bladder, with little or no urine. This complication can be derived from a urogenital infection and is usually accompanied by pain and cramps.
In these cases, uromycin treatment should be applied a little more aggressively, to eliminate any infectious lag. When the analgesic action of phenazopyridine, present in uromycin, is not sufficient, the doctor can prescribe a more powerful analgesic, without stopping uromycin intake.
Uromycin works against bacteria in urine
Uromycin capsules are recommended for the treatment of infections caused by gram-positive and gram-negative bacteria present in the urine.
Uromycin is used for surgical treatment
Uromycin is used as a medicine to prevent infections in the pre and post operative stages of the organs associated with the urinary tract such as prostactectomies. It is also used in permanently catheterized patients and patients with urethral reflux and other related complications.
How uromycin works
The therapeutic action of uromycin is conditioned by its three active components:
Sulfamethizole, as a sulfonamide, is a synthetic broad-spectrum bacteriostatic antibiotic against most gram-positive and many gram-negative organisms. Sulfamethizole acts as a competitive inhibitor of p-aminobezoic acid during the metabolic cycle of folic acid, preventing the bacteria from multiplying.
Tetracycline is a short-acting antibiotic that prevents bacterial growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. Furthermore, tetracycline can alter the cytoplasmic membrane of bacteria causing the fatal loss of intracellular contents, such as nucleotides, from the cell.
Tetracycline passively diffuses through channels in the bacterial membrane and binds reversibly to the 30S ribosomal subunit, preventing the binding of tRNA to the mRNA-ribosome complex, thus interfering with protein synthesis.
Action of Phenazopyridine
Phenazopyridine is a local anesthetic that is commonly used in urinary tract disorders. However, its use is quite restricted because it is associated with toxicity problems, mainly blood disorders, and a high risk of cancer development.
The mechanism of action of phenazopyridine is not fully known, and only basic information is available about its interaction with the body. What is known is that the chemical has a direct topical analgesic effect on the lining of the urinary tract mucosa. It is rapidly excreted from the kidneys rapidly through the urine.
Adult uromycin dosage
For adults the recommended dose is 1 tablet of 250 mg twice a day. In the case of a severe infection, the doctor should normally increase the dose to 500mg 2 times a day. In both cases, the usual duration of treatment is 7 to 14 days.
If the patient has an infection with kidney involvement, then the dose should be reduced by half. That is, 250mg once a day or 250mg 2 times a day in the case of severe infections.
Its oral administration is recommended especially in situations of urinary infection that can become serious complications.
Uromycin dosage for children
For children, from 6 months, the usual daily dose is 15 mg / kg divided into 2 daily doses for a maximum period of 10 days. When it comes to mycobacterial infections, the maximum dose for children is 500 mg daily.
This medicine is sold by prescription, so it is advisable to go to a medical professional for its prescription. It should be remembered that, as it is an antibacterial, if the dose is not complied with, the bacteria could develop resistance to the drug.
Other pills for urinary infection
It has an anti-inflammatory and antilysiatic action on the urinary tract. It also exerts an action from the kidney that helps eliminate kidney stones.
It is a very powerful antibiotic that is prescribed to treat urinary tract infections.
It is indicated to combat very acute or chronic urinary tract infections.
Its active ingredient is sulfamethizole, which is prescribed to treat urinary tract infections.
It is indicated for the control of urinary infections that are generated by gram-negative microorganisms, mainly Escherichia coli and Proteus.
Precautions for taking uromycin
- The consumption of uromycin is contraindicated in patients with hypersensitivity to the active components of the drug.
- Under no circumstances should it be administered to patients at any stage of pregnancy. Nor to children who are less than 6 years old.
- Patients suffering from chronic glomerular nephritis and pyelonephritis cannot consume uromycin, or any of its active substances.
- The patient’s allergy history should be kept in mind as an allergic reaction may occur due to exposure to this drug since it is a sulfa drug.
Uromycin side effects
The adverse effects as a consequence of uromycin treatment are quite varied. Some forms of toxicity can occur as a consequence of the reaction to the metabolism of sulfa drugs. As a result of these toxicities, the following clinical events have been documented: Acute hemolytic anemia, agranulocytosis, aplastic anemia and crystalluria.
There were also cases of hypersensitivity with mucocutaneous manifestations, rashes, urticaria, erythema multiforme, exfoliative dermatitis and photosensitivity.
As a consequence of the reaction to tetracyclines, uromycin can cause gastrointestinal discomfort, heartburn, nausea, vomiting and diarrhea.
Dr. Samantha Robson ( CRN: 0510146-5) is a nutritionist and website content reviewer related to her area of expertise. With a postgraduate degree in Nutrition from The University of Arizona, she is a specialist in Sports Nutrition from Oxford University and is also a member of the International Society of Sports Nutrition.