The trimebutine is a drug commonly used as a regulator of motility in treating various gastrointestinal complications. Due to its affinity for stimulating and suppressing receptors, it serves to control the movement of the smooth muscles of the intestine. It is also used for the treatment of irritable bowel, for diarrhea and other digestive system problems.

What is trimebutine?

Trimebutine is the International Nonproprietary Name (INN) that receives an antispasmodic drug generally prescribed for cases of irritable bowel. Observing the pharmacological classification, trimebutine belongs to the groups of “Myotropic spasmolytics” and “stimulants of gastrointestinal motility”.

By combining with opioid receptors, trimebutine influences the smooth muscle mechanism of the gastrointestinal tract. In this way, it acts as a regulator of alterations in motor function, independently of the central nervous system.

What is trimebutine for?

Gastrointestinal complications bring with them a sequel of diseases and unpleasant health conditions that alter the tranquility of the person. Trimebutine is one of the most effective medications to help improve these conditions. Let’s see what trimebutine is for.


Diarrhea is one of the symptoms that most commonly manifests itself during poor digestive tract function. Although there are many medications to treat it, trimebutine is one of those that has been shown to be most effective. However, a therapeutic review is required that involves other measures, by the treating physician, to find the origin of the cause and complement the treatment.


An inflammation of the gastric mucosa or gastritis, as it is more commonly known, is caused many times by excess alcohol and tobacco, the consumption of foods with saturated fats continuously, or a specific type of bacteria. In these cases, trimebutine is relevant for the optimization of medicinal therapy that helps to improve these annoying symptoms.


Irritable bowel or colitis, is a pathology that has as a characteristic feature the inflammation of the mucous membrane of the intestine. Its efficacy on gastrointestinal motility disorders and visceral hypersensitivity, makes trimebutine a good drug for colitis.

Stomach ache

Trimebutine relieves stomach pain, one of the most frequent and most painful symptoms of gastrointestinal diseases, many times caused by bacteria, viruses and parasites; as well as by eating food in poor condition or with excess saturated fat.

Facilitate defecation

After abdominal surgery, it is difficult to return to normal bowel function, mainly to avoid straining to expel the stool. Trimebutine in this case, serves to restart defecation after a surgery of this type, and to prevent intestinal obstruction.

Trimebutine for weight loss

Indeed, the good gastrointestinal health that is obtained with trimebutine, without a doubt, is an important factor to achieve the ideal weight, since it allows to expel intestinal waste in time, which when accumulated, can lead to an increase in unwanted weight.

In what presentation can we find Trimebutine?

Due to the various forms of administration, trimebutine is marketed in different presentations. Each of these contains a different composition, therefore, it is important to ingest the one that has been indicated by the doctor.

Trimebutine with simethicone or dimethicone

Trimebutine with simethicone or dimethicone, as it is also known, combines the potency of both drugs for the treatment of the gastrointestinal tract.

Trimebutine tablets and capsules

Trimebutine tablets can be found in 100 mg, 200 mg, and 300 mg. In addition to trimebutine maleate as an active substance, they may contain excipients that modify the impact on the patient’s body.

Pediatric Trimebutine

Pediatric trimebutine is indicated in children with severe dysfunction of gastrointestinal functions. Therefore, it serves to normalize the movement of the intestinal tract in these types of patients, slowing down or accelerating contractions as the case may be. This pediatric presentation only exists in 100 ml syrup or suspension, which contains sucrose, orange aroma and yellow coloring, so that it is more and better accepted by children.

Trimebutine solution for injection

This injectable presentation of 50 mg or 5 ml of trimebutine maleate, is for intravenous or intramuscular use. It is indicated as a faster way to relieve symptoms when symptoms persist with other treatments.

Trimebutine dosage

The doses of trimebutine prescribed by the doctor should always be based on the patient’s conditions. However, in general cases, the recommended doses of this medicine are as follows:

Pediatric trimebutine dose

In children, trimebutine is indicated to relieve vomiting and to decrease diarrhea. The presentation of this medicine is in pediatric suspension for children 6 years and older, who weigh at least 20 kilos. The recommended intake is 10 to 20 mg a day, for each kg of weight, which should be administered in three doses a day, before each meal.

Trimebutine dosage for adults

The indication of trimebutine for adults begins with 400 mg per day, 15 to 30 minutes before meals. After alleviating the symptoms, the specialist’s recommendation is to continue with 200 mg daily until the end of the treatment, which can last between 4 to 8 weeks.

Trade name of Trimebutine

Trimebutine drugs are produced by various pharmaceutical laboratories. This generates a variety in the commercial name of trimebutine, the following being the best known:

  • Trimebutine spabion : produced by Degort’s Chemical, trimebutine spabion in suspension being the most commercialized product.
  • Miopropan trimebutine : prepared by Laboratorios Bernabo SA
  • Dolbutin trimebutine : manufactured by Laboratorio Mavi.
  • Smoked trimebutine : produced and sold at Farmacias Ahumada (Chile).
  • Libertrim trimebutine : manufactured at Carnot Laboratories.
  • Debridat trimebutine : produced by the transnational Pfizer.
  • Generic trimebutine : this is the name by which the original medicine is known.
  • Generic Simethicone Trimebutine : It is the mixture of trimebutine and simethicone without brand name.

Trimebutine price

The price of trimebutine varies between 50 and 100 euros, according to various factors, such as brand, presentation and place of sale. Therefore, the establishment closest to the patient should be consulted.

Contraindications of trimebutine

Trimebutine and alcohol intake

Because it can alter its function, the patient should not drink alcohol when taking trimebutine. In addition, the consumption of this drug could aggravate the inflammation that is being treated with trimebutine.

Use of trimebutine during pregnancy

The use of this medicine is not recommended in pregnant women. In case of gastrointestinal complications during this period of time, the patient should inform the doctor about what medications to take.

Use of trimebutine in lactation

The absorption of this medicine through breastfeeding is not proven or ruled out. Therefore, there are chances of putting the baby at risk if the mother takes trimebutine during this time.

Other important contraindications are: patients with myasthenia gravis and in patients who have hypersensitivity to the components of trimebutine.

Side effects of trimebutine

The components of trimebutine may cause the following side effects:

  • Dry mouth
  • Heartburn
  • Sickness
  • Diarrhea
  • Constipation
  • Drowsiness
  • Headaches

Conclusion on the use of Trimebutine

Trimebutine is a drug that has proven to be very effective in treating digestive tract problems, and its use has been extensive throughout the world. An adequate intake can help the patient to have a better quality of life and minimize the risks and side effects that its intake entails.

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Dr. Samantha Robson ( CRN: 0510146-5) is a nutritionist and website content reviewer related to her area of ​​expertise. With a postgraduate degree in Nutrition from The University of Arizona, she is a specialist in Sports Nutrition from Oxford University and is also a member of the International Society of Sports Nutrition.

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