Secnidazole is a drug that is synthetically derived from 5-nitroimidazoles and is used as an antimicrobial and antiprotozoal. Its pharmacological formula is used for the treatment of infections by anaerobic bacteria and protozoa.

This drug is one of the most recommended by specialists to treat cases related to bacterial vaginitis, all types of amoebiasis and parasitic conditions that attack important organs such as the liver, intestines and stomach.

What is secnidazole and what is it for?

Secnidazole is a new generation active substance that is used to fight various bacterial and intestinal infections and many types of amoebiasis. Although it is quite effective for these types of treatments, it is important to note that it has no effect against viral-type infections.

This drug is within the category of nitroimidazoles with long-acting antibacterial action. Its bactericidal effect is more active against unicellular microorganisms such as trichomonas vaginalis, intestinal lamblia, entamoeba histolytica and other amoebas.

The properties of this drug have proven to be very effective in treating the following pathologies:

Secnidazole for vaginitis and urethritis caused by trichromones

Trichomoniasis is known as one of the sexually transmitted diseases that affects people the most. The main victims of this infection are women, since it attacks their genital organs and can cause serious complications. Secnidazole is used to treat this STD, because it alters the DNA of trichomonas and prevents their reproduction.

Secnidazole in intestinal amebiasis treatment

Intestinal amebiasis is one of the most common reasons that health professionals often prescribe secnidazole. Although its use is recommended for this type of intestinal infections, at no time is the patient encouraged to use this drug without a prescription.

Secnidazole to treat hepatic amebiasis

Because it causes ongoing blood loss, hepatic amebiasis often causes weakness and anemia in those who have it. In these cases, the use of secnidazole has had excellent results as a drug for treatment and control.

Secnidazole is used for parasitic infections

When an individual is infected by parasites, he is exposed to the risk of serious damage, and may even lose his life. The intake of secnidazole in adequate doses allows to kill the parasites and protect the organism against new infections.

Secnidazole to treat Giardiasis

It is an intestinal-type infection caused by a parasite that lives in the feces of animals and humans. Symptoms of giardiasis include aggressive diarrhea that causes weakness and dehydration in the patient. In these cases, doctors usually prescribe secnidazole to eliminate the underlying problem, in addition to treatment for dehydration.

Depending on the doctor’s judgment, this drug may also be used to treat other diseases or conditions, such as:

Mechanism of action of secnidazole

The pharmacodynamic action of secnidazole occurs as a result of the penetration of the active substance into the medium of the microorganism. There, thanks to the 5-nitro group, secnidazole is restored and begins to attack cellular DNA.

The cell of the microorganism dies due to damage to the DNA structure, destruction of the filaments and the suppression of the integrity of the nucleotides. In this way, it alters the normal synthesis of nucleic acids in bacteria, preventing them from replicating and reproducing.

On the other hand, it has not been possible to demonstrate any kind of usefulness of this drug to combat aerobic bacteria.

How to take Secnidazole?

Regarding the dose, the amounts and frequencies for the use of secnidazole differ according to the age and weight of the patient. It should be borne in mind that the composition of each presentation may vary according to each country or brand. Therefore, it is advisable to consult the information attached to each package before defining the dosage for the treatment.

To determine the appropriate dose and time of treatment, the doctor must pre-test the patient. Therefore, the following indications and doses should only be viewed as a guide.

Secnidazole pediatric dose

The pediatric dose of secnidazole depends on the type of infection targeted by treatment.

  • Intestinal amebiasis and giardasis in children : to treat these infections, specialists recommend administering a dose of 30 mg for each kilogram of weight per day. This treatment should only be administered to children older than 2 years and a maximum of 2 g per day.
  • Hepatic amebiasis in children : The recommended dose of secnidazole for the treatment of hepatic amebiasis in children is 30 mg per kilogram of weight for 5 to 7 days. The maximum daily dose cannot exceed 2 g and the treatment can only be received by children older than 2 years.

In cases of Giardasis, treatment should be extended to everyone who is part of the child’s environment. This is the only way to eradicate the disease and prevent future outbreaks.

Secnidazole adult dose

The dose of secnidazole in adults varies according to the type of disease to be treated and the sex of the patient.

  • Intestinal amebiasis in adults : a single dose of 2000 mg is recommended for male patients, and 1500 mg for female patients. However, if it is amoebiasis in its cystic form, the treatment should be extended to 3 days.
  • Hepatic amebiasis in adults : for the treatment of hepatic amebiasis, it is recommended to take 500 mg of secnidazole 3 times a day for a period of 5 to 7 days. In this case the dose is the same in both men and women.
  • Urethral or vaginal trichomoniasis: in cases of trichomonas infections, the recommended dose is a single dose of 2000 mg of secnidazole. To ensure the effectiveness of the treatment, the patient’s sexual partner will also have to ingest the corresponding dose.

The time it takes for the effects of this medicine to appear varies according to the dose and route of administration. This does not mean that in order to quickly regain health, the dose prescribed by the doctor can be increased.

Presentation of secnidazole

Basically, secnidazole is marketed in two forms, tablets and suspension or granules.

Tablets: 500 mg and 1000 mg or 1 g. Secnidazole 1g tablets are for exclusive use in adult patients who require treatment against severe infections. Its administration is limited to 2 pills or tablets equivalent to 2g per day.

Suspension or granules: Secnidazole in granulated suspension is sold in bottles of 9 g and 4.5 g of the drug to create a solution. After mixing, a total of 150 mg of secnidazole is obtained for every 5 ml of the solution.

Contraindications of secnidazole

Secnidazole and alcohol use

When receiving a treatment with secnidazole, you should avoid drinking beverages that contain alcohol, as it can cause effects such as a rise in temperature, redness, rapid heartbeat or nausea with vomiting.

Secnidazole in allergic patients

One of the compounds of this drug in tartrazine, a substance that can cause allergies, including bronchial asthma in patients who are susceptible to this component.

Secnidazole and other drugs

Taking secnidazole with disulfiram can cause confusion and delirium. In the case of taking a treatment with oral anticoagulants such as warfarin, there may be a risk of bleeding related to liver metabolism.

With regard to lithium, the patient may experience toxicity. In other patients taking phenobarbital, there may be a decrease in the effectiveness of Secnidazole.

Secnidazole in pregnancy

Some studies have not anticipated the consequences. Therefore, the recommendation for pregnant women is to take secnidazole only after the third month of pregnancy is over, when the benefits outweigh the risks.

Conclusion on the effective use of secnidazole

The effective action that secnidazole has in the body to treat many infections caused by different pathogens is remarkable, however, emphasis is placed on the care that the intake of this medicine requires, like many others, since an excess or inappropriate use can bring consequences or inhibit its effectiveness.

Samantha Robson
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Dr. Samantha Robson ( CRN: 0510146-5) is a nutritionist and website content reviewer related to her area of ​​expertise. With a postgraduate degree in Nutrition from The University of Arizona, she is a specialist in Sports Nutrition from Oxford University and is also a member of the International Society of Sports Nutrition.

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