Progesterone is an organic substance, better known as a hormone that is secreted by specialized cells, which when they enter the bloodstream influence a set of properties and functions of some organs and tissues of the body. In some cases, they occur in just seconds, and in others, they can take as long as a day or a year.

Its secretion is located in the endocrine gland, involving organs such as the hypothalamus, the pituitary, the thyroid, the pancreas, the reproductive glands, the placenta, and in certain cases, the small intestine.

In plants, progesterone has been found to be produced in walnut. Although in species like yam, they produce substances similar to this hormone. In humans and animals, progesterone is derived from cholesterol, but this substance can also be obtained through technological procedures, starting from walnut and yam.

This hormone has key effects on various organs of the human body, the main ones being: the reproductive system, playing a leading role in both menstruation and pregnancy; in the nervous system, activating and deactivating parts of the body, allowing it to adapt to circumstances in real time.

The hormone participates in the development of female sexual characteristics and acts in specific developmental stages of women. Thus, in pregnancy, it is in charge of conditioning the mammary glands for the maternal breastfeeding process. In the same way, in the menopause stage it acts as a substance that relieves and calms the discomforts manifested in this stage.

Role of progesterone and estrogens in the body

Both progesterone and estrogens are hormones of the first order in the sexual development of women, acting in a balanced way in the development of the human embryo, and in female sexual maturity.

However, an imbalance in the segregation of one of them means the failure of the other, generating collateral effects that alter both the sexual life of the woman, her psychological well-being and the affectation of some organs.

Thus, a low level of progesterone in women leads to female sterility, and other symptoms such as the presence of premenstrual discomfort, spontaneous abortions, and breast tenderness. In the same way, the presence of low levels of estrogens causes an increase in cholesterol and the accumulation of fats in organs.

Other symptoms generated by this situation are the manifestation of depressive states, irritability and bad mood, and in many cases, the appearance of calcium deficiency in the bones.

What is progesterone for in pregnancy?

The leading role that progesterone assumes during pregnancy assigns custody to it throughout the process of new life formation. From the beginning of pregnancy, this hormone governs the main processes that guarantee a safe pregnancy.

In the first phase, it nourishes the fertilized egg and allows it to adjust to the wall of the uterus. And throughout the pregnancy, its secretion ensures the healthy growth of the fetus.

However, when low levels of hormone secretion occur, the pregnant woman is placed at risk of miscarriage. Therefore, to solve this situation, specialists in the area prescribe synthetic progesterone until its production stabilizes naturally.

Likewise, this hormone acts positively in the formation of urine during pregnancy, thus limiting fluid retention and its inflammatory effect, common symptoms during this stage.

Progesterone in menopause

The woman has a stage in life in which she stops menstruating, which occurs between the ages of 48 to 54 years, since ovarian function ceases and the production of estrogens and progesterone is reduced. When this process begins, discomforts that afflict the woman begin to appear, such as: episodes of intense heat; excessive sweating; insomnia; tachycardia; sudden mood swings; dry skin and vaginal mucus; decreased libido.

However, the shortage in the production of progesterone and estrogens also influence the lack of calcium in the bones and the production of cholesterol, for which the artificial replacement of these two substances is necessary, and thus minimize the risks that they represent. its limited production for the body.

Your prescription must be supplied and supervised by a specialist in the area, since according to clinical tests, the use of estrogen can cause diseases such as cancer. It is important that a doctor follows the treatment, controls the doses and the ways of application. In this way, the best possible state of health will be maintained.

What is progesterone cream for?

Progesterone cream is a product made from the processing of plants such as yams. This substance is recommended when there are imbalances in the levels of estrogen and progesterone in the body.

Its presentation in cream or gel is commonly used in two ways: rubbed two or three times a day in the urinary tract – genital; internally, covering the uterus and vagina.

In most cases, the recommended dose is 15 to 24 mg per day, for 14 days. In those cases that are recommended to improve premenstrual symptoms, its application should be carried out before its appearance, stopping its supply one day before menstruation.

Progesterone side effects

When this hormone is prescribed, the possible side effects that may appear during the period in which the treatment is being applied must be taken into consideration. Thus, if progesterone is consumed orally and the symptoms listed below appear, it is recommended that you go immediately to the nearest medical center:

  • Tongue and hands feeling heavy or stiff.
  • Lack of concentration and constant dizziness.
  • Very repetitive hot flashes.
  • Persistent nausea
  • Vertigo and auditory and tactile hypersensitivity.

If symptoms persist for several days, it is important to consult with your trusted doctor to determine if it is the medication that is causing these symptoms. If so, it will be the specialist who changes and controls the treatment afterwards.

Contraindications of progesterone

The prescription and use of progesterone is contraindicated in the following cases:

  • Cancer in the reproductive organs, or in the breasts.
  • In the period of pregnancy.
  • In incomplete abortions.
  • Genital bleeding from unknown causes.
  • In clinical cases triggered by obstruction of the venous system.
  • Liver diseases.
  • In ear affections.
  • Periods of drowsiness

Likewise, its administration should be strictly monitored when applied in the following cases: kidney and heart failure; asthma; severe headaches; metabolic diseases of hereditary origin; and when there is a history of depression.

The special cases that require greater vigilance when this substance is administered are: its use in ointment during the breastfeeding period, its use in the form of pills is not recommended; when performing work and / or daily activities that require precision, attention and / or concentration, since its use produces drowsiness and a feeling of vertigo.

It is recommended that if symptoms such as: weight loss, back pain, or stomach pain, recurrent nausea, vaginal irritation, depression and mood changes occur, that you go to the nearest medical center to strictly monitor your consumption. . A doctor will need to assess your situation and decide whether it is appropriate to change your treatment or eliminate it completely.

Samantha Robson
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Dr. Samantha Robson ( CRN: 0510146-5) is a nutritionist and website content reviewer related to her area of ​​expertise. With a postgraduate degree in Nutrition from The University of Arizona, she is a specialist in Sports Nutrition from Oxford University and is also a member of the International Society of Sports Nutrition.

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