Naphazoline (in hydrochloride form) is the common name for 2- (1-naphthylmethyl) -2-imidazoline hydrochloride. It is a sympathomimetic agent with marked alpha adrenergic activity. The non-hydrochloride form of naphazoline has the molecular formula C14H14N2 and a molar mass of 210.28 g / mol. The HCl salt form has a molar mass of 246.73 g / mol.

For which diseases Nafazoline is prescribed

It is a fast acting vasoconstrictor to reduce swelling when applied to the mucous membrane. It acts on the alpha receptors in the arterioles of the conjunctiva to produce constriction, which results in a decrease in congestion. It is an active ingredient in several over-the-counter formulations including eye drops.

Naphazoline is a decongestant used to relieve redness, swelling, and itching or watering of the eyes due to colds, allergies, or eye irritation (smog, swimming, or wearing contact lenses). It is known as a sympathomimetic (alpha receptor agonist) that works in the eye to decrease congestion.

Some brands of naphazoline eye drops also contain other ingredients. Lubricants (such as glycerin, hypromellose, or polyethylene glycol 300) help protect the eyes from further irritation. Zinc sulfate, an astringent, helps reduce redness and irritation.

Indications on how to use Nafazoline

Follow all directions on the product package, or use as directed by your physician. If you are not sure about the information, ask your doctor or pharmacist.

To apply eye drops, wash your hands first. To avoid contamination, do not touch the dropper tip or allow it to touch your eye or any other surface.

Remove contact lenses before applying eye drops. Wait at least 10 minutes after using this medicine before inserting contact lenses.

Before use, check this product visually. Do not use if the liquid has changed color or is cloudy. Use in affected eye (s) as directed.

Tilt your head back, look up, and lower your lower eyelid to make a pocket. Hold the dropper directly over the eye and put 1 drop in the bag. Look down and gently close your eyes for 1 to 2 minutes. Place a finger at the corner of the eye near the nose and apply gentle pressure. This will prevent the medicine from draining away from the eye. Try not to blink and don’t rub your eye. Repeat these steps if your dose is more than 1 drop and for the other eye, if indicated.

Do not rinse the dropper. Replace the dropper cap firmly after each use.

If you are using another type of eye medicine (for example, drops or ointments), wait at least 5 minutes before applying other medicines. Use eye drops before eye ointments to allow the drops to enter the eye.

Excessive use of this type of medicine can lead to increased redness in the eyes (rebound hyperemia). Tell your doctor if this occurs or if your condition persists or worsens after 48 hours.

Nafazoline side effects

May cause stinging, redness, dilated pupils, or blurred vision. If any of these effects persist or get worse, tell your doctor or pharmacist as soon as possible.

If your doctor has directed you to use this medicine, remember that he has judged that the benefit to you is greater than the risk of side effects. Many people using this drug do not have serious side effects.

Tell your doctor right away if any of these unlikely but serious side effects occur: dizziness, nausea, sweating, drowsiness, weakness, nervousness, worsening redness / itching / swelling in or around the eyes.

Tell your doctor right away if you have any of these rare but very serious side effects: eye pain, other vision problems, headache, low body temperature, irregular heartbeat.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any of the following symptoms of a severe allergic reaction: rash, itching / swelling, severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Contraindications of Nafazoline

Before using this medication, tell your doctor or pharmacist your medical history, especially of: heart problems (eg, high blood pressure), glaucoma, diabetes, eye infection / injury, overactive thyroid (hyperthyroidism).

After applying this medicine, your vision may become temporarily blurred. This medicine may also make you dizzy or drowsy. Alcohol or marijuana can make you feel more dizzy or sleepy. Don’t drive, use machinery, or do anything that requires alertness or clear vision until you can do it safely. Limit alcoholic beverages.

Caution is advised when using this medication in children, as they may be more sensitive to its effects, especially severe drowsiness and severely lowered body temperature.

During pregnancy, this medicine should only be used when clearly needed. Discuss the risks and benefits with your doctor.

It is not known if this drug passes into breast milk. Consult your doctor before breastfeeding.

Nafazoline cautions and warnings

Some warnings and contraindications that apply to all substances containing naphazoline for medicinal use are:

  • Patients taking MAO inhibitors can experience a severe hypertensive crisis if they are given a sympathomimetic drug such as naphazoline hydrochloride.
  • Use in infants and children can cause central nervous system depression, leading to coma and a marked reduction in body temperature.
  • It should be used with caution in patients with severe cardiovascular disease, including cardiac arrhythmia, and in patients with diabetes, especially those with a tendency to diabetic ketoacidosis.
  • Drug interactions can occur with anesthetics that sensitize the myocardium to sympathomimetics (eg, cyclopropane or halothane with caution).
  • Take care when applying before using phenylephrine.
  • Long-term use can cause drug rhinitis, a rebound nasal congestion condition.
  • A possible association with stroke has been suggested.

Trademarks and presentations of Nafazolina

It is available over the counter and is found in eye products such as Eucool, Clear Eyes, and Naphcon.

More information about Nafazolina

Do not use this medicine while wearing contact lenses. Naphazoline ophthalmic may contain a preservative that can discolor soft contact lenses. Wait at least 15 minutes after using this medicine before putting on your contact lenses.

Ask a doctor or pharmacist if it is safe for you to use if you are also using any of the following medications:

  • an antidepressant: amitriptyline, clomipramine, desipramine, desvenlafaxine, doxepin, duloxetine,
  • imipramina, maprotilina, milnacipran, nortriptilina, venlafaxina;
  • ergotic medicine: ergotamine, dihydroergotamine, ergonovine, methylergonovine; o
  • un inhibidor de la MAO: furazolidona, isocarbox, linezolido, phenelzine, rasagiline, selegiline.

Tell the doctor about all medicines you take. This includes prescription and over-the-counter drugs, vitamins, and herbal products. Don’t start a new medicine without checking with your doctor.

Samantha Robson
 | Website

Dr. Samantha Robson ( CRN: 0510146-5) is a nutritionist and website content reviewer related to her area of ​​expertise. With a postgraduate degree in Nutrition from The University of Arizona, she is a specialist in Sports Nutrition from Oxford University and is also a member of the International Society of Sports Nutrition.

Similar Posts

Leave a Reply

Your email address will not be published. Required fields are marked *