The MIOPROPAN S is a drug comprising Simethicone (anti flatulent-effect) in combination with trimebutine (antispasmodic), used to treat the symptoms caused by Irritable Bowel Syndrome. This works by reducing the hypersensitivity of the viscera, thus relieving pain and discomfort such as diarrhea or constipation. Once motility is regulated, the release of intestinal gas is greatly facilitated.

Uses of Miopropan S

This medicine belongs to the group of antispasmodics and anxiolytics, as it takes care of the motility of the digestive system. It is generally indicated to treat:

  • The characteristic postprandial pain of Irritable Bowel Syndrome.
  • Symptoms of Irritable Bowel Syndrome: constipation and alternating diarrhea.
  • Helps to regain regular bowel function after surgery.
  • Abdominal pain caused by intestinal functional disorders, such as: flatulence, bloating, belching, abdominal distension, aerophagia.
  • Increased gastrocolic reflex.
  • Diverticulosis, whether or not it is present.
  • Non-ulcer dyspepsia, with previously negative gastric endoscopy.

It is important for you to know that this medicine cannot be used to treat colic in children.

Recommended dose of Mipropan S

Usually the indicated dose of this medicine consists of 1 to 3 tablets of 200mg a day, before meals. Although said dose will be subject to the judgment of the treating physician and will vary depending on the patient’s symptoms. Normally this treatment does not exceed 3 months. For those who are elderly or suffer from liver or kidney failure, the dose should be lower than that mentioned above.

Composition of Miopropan S coated tablets

  • 200 mg of Trimebutine Maleate
  • 120 mg of Simeticona
  • 270 mg of Tricalcium Phosphate
  • 150 mg of microcrystalline cellulose
  • 75 mg de Crospovidona
  • 62 mg de Povidona
  • 30 mg of silicon dioxide
  • 30 mg of Polyvinyl Alcohol / Titanium Dioxide / Polyethylene Glycol / Talc
  • 25 mg of Sodium Stearyl Fumarate
  • 30 mcg of Defoamer
  • 1280 mg of Lactose csp

Presentation of the Miopropan S

This medicine comes in the following presentations: packs of 20 and 40 tablets. Miopropan 200 mg, comes in packs of 20, 30 and up to 60 tablets. The extemporaneous suspension comes in a 250 ml container.

Pharmacological action of Miopropan S

The action of Trimebutine, one of the components of this drug, is carried out by two mechanisms: firstly, as an agonist of the encephalinergic receptors of the intestinal myenteric network and, secondly, through the release of gastrointestinal peptides, such as This is the case of motilin.

Under certain conditions, it can affect the postprandial increase in gastrin, polypeptides, glucagon, pancreatic, among others. In addition, it tends to stimulate intestinal motility like fasting, inhibiting postprandial motility, which results in the migratory motor complex. Through these mechanisms, intestinal transit is modulated, reducing visceral pain caused by colorectal distention.

In the case of simethicone, it represents a surfactant agent that works by dispersing and preventing the formation of muco-gaseous bubbles, reducing their surface tension. In this sense, it is an agent that prevents flatulence, which calms abdominal discomfort and pain, caused by excess gas in the intestinal mucus.

Pharmacokinetics of Miopropan S

Simethicone is not absorbed, therefore it is excreted in the stool. For its part, if Trimebutine is completely absorbed, the percentage of the dose that is eliminated as various metabolites per kidney is 94%. The maximum peak of plasma concentration is perceived 1 or 2 hours after having been administered to the patient.

Nortrimebutine, which is the main metabolite of trimebutine, is constituted in the liver, exerting its action in the rest of the digestive tract, especially in the colon and crossing the placenta.

Adverse effects of Miopropan S

In general, the side effects of this drug tend to disappear after a couple of hours, however, if not, the most prudent thing is to suspend the treatment and immediately consult the treating doctor or, failing that, go to the hospital emergency room. . Some of the symptoms are as follows:

  • Diarrhea.
  • Abdominal constipation
  • Sensitivity of the skin to cold or heat.
  • Mild to severe dizziness.
  • Excessive tiredness.
  • Dry mouth

Miopropan S interactions

Some of the interactions that may occur during treatment are:

  • The efficacy of cisapride is reduced when the patient is taking medications composed of trimebutine.
  • On the other hand, the joint use with Procainamide tends to enhance the antivagal effects, especially on cardiac conduction.
  • In combination with Zotepine, it potentiates the anticholinergic effects, with the risk of other undesirable effects such as insomnia, agitation, gastrointestinal upset, delirium.

Contraindications and warnings about the use of Miopropan S

This medicine is contraindicated for women who are pregnant, especially in the first trimester or who are breastfeeding. In the same way, it is contraindicated for patients who have intestinal obstruction or perforation of any kind.

On the other hand, it is important that you consider that the symptomatic response to treatment with this drug does not rule out the existence of a certain organic process that causes alterations in the motility of the digestive tract, such as neoplasia, chronic intestinal infection or acute, diverticulosis, parasitosis, among others.

Remember not to use the medicine once it has passed the expiration date, nor exceed the recommended dose. Because it contains lactose, its use is contraindicated for those patients suffering from glucose and galactose malabsorption syndrome, congenital galactosemia or lactase deficiency.

Miopropan S overdose

Although an overdose with this medicine rarely occurs, in case of accidental occurrence, the symptoms could manifest as diarrhea, nausea, drowsiness or fainting. If 1 hour has not passed since ingestion, vomiting can be induced or gastric lavage can be performed. If not, it is advisable to attend the hospital emergency.


Miopropan S is a drug that is indicated for the treatment of a set of digestive pathologies, especially those associated with Irritable Bowel Syndrome. Its mechanism of action on the digestive tract is anxiolytic and antispasmodic type. It is important that a series of precautions and warnings are considered before starting treatment, in addition to following the doctor’s instructions to obtain better results that translate into improvement.

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Dr. Samantha Robson ( CRN: 0510146-5) is a nutritionist and website content reviewer related to her area of ​​expertise. With a postgraduate degree in Nutrition from The University of Arizona, she is a specialist in Sports Nutrition from Oxford University and is also a member of the International Society of Sports Nutrition.

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