The kenocotazol , is an antifungal used as antifungal therapy is able to treat symptoms and diseases affecting the skin thrush, dandruff, vaginal infections and mycoses in the dermis. This medicine interferes to prevent the growth of fungi that produce large infections that must be treated under the indications of a specialist doctor.

What is it for and what are the benefits of ketoconazole

The drug ketoconazole is an antifungal that belongs to the imidazole groups, which are antifungals that have the ability to act on the cell walls of fungi. It has the function of attacking fungal infections in the dermis, especially if it is ringworm and cutaneous candidiasis, helping to prevent and prevent fungi from expanding and multiplying.

The action of ketoconazole interferes with the synthesis of the membranes of microbial cells. It has the ability to prevent ergosterol, which is a substance that belongs to the membrane of fungi, from being synthesized and interacting with the enzyme called 14-alpha demethylase belonging to the hemoprotein, so that ergosterol is created. This will prevent the cell membrane of the fungi from being altered and in turn stop reproducing without affecting human cells.

Ketoconazole is widely used to treat fungal infections internally and externally. Its different presentations have a high antifungal power to locate and attack the various conditions caused by fungi that affect the skin, vagina, scalp, nails and some gastrointestinal organs.

Ketoconazole presentations

The kenocotazole drug, can be obtained in various presentations, these are drunk and used as prescribed by the doctor and according to the symptoms present. They are between them:

pills

  • The use of tablets is used in cases of serious infections, their action stops the growth of fungi.
  • It is used in cases of candidiasis, histoplasmosis, blastomycosis, dermatophytosis, irregular spots or peeling of the skin when scratching.
  • Your dosage should be 200 milligrams once a day along with food, this dose can increase to 400 milligrams depending on the infection.

Shampoo

  • It is used in cases of severe dandruff or seborrheic dermatitis.
  • It should be applied daily for 4 weeks. It should be left on for 5 minutes and then rinsed with plenty of water.

Cream

  • The cream can only be used on the skin, it is important to clean and dry the area where it will be applied well, to avoid contaminating factors and thus prevent reinfection.
  • It is used to treat skin infections such as jock itch, athlete’s foot, shingles, fungal infections, nail infections, dermatitis, and various fungi.
  • It should be applied every 24 hours, for 2 to 4 weeks.

Vaginal ovules

  • It is an imidazole antifungal, which is used to treat infections caused by fungi that form in the cell wall membrane. The action of the ovules minimizes the production of these fungi.
  • One 400-milligram egg should be placed before bedtime, until symptoms have disappeared and tests show negative results.

Precautions to be taken with the use of ketoconazole

When using ketoconazole treatment, it is very important to keep the following precautions in mind:

  • If you want to achieve an effective action to eradicate the infection, it is necessary to use this drug for the time indicated by the doctor, even if the symptoms have improved, since stopping the treatment can cause a relapse.
  • In case the person has severe headaches, hypersensitivity or irritation, the use should be discontinued immediately and consult the attending physician.
  • If, when noticing that the problem remains the same or worsens, the doctor should be called to take the necessary measures.
  • If the patient is allergic to ketoconazole or any of its components, this medicine should not be used.
  • Skipping doses should be avoided, this could lead to the risk of contracting an additional infection that is resistant to this drug.
  • While this medicine is being used, the affected parts of the skin should not be covered with bandages.
  • It is important to be careful to avoid that ketoconazole does not enter the nose, mouth or eyes, if this happens you should wash the area with plenty of water.
  • If symptoms of irritation, acute burning, suppuration, pain or redness are noted at the beginning of treatment, the use of ketoconazole should be discontinued immediately.
  • Ketoconazole should not be used around fire or smoking, as it is flammable in cream or gel.
  • Clothing with tight synthetic fabric should be avoided while using this treatment, as it does not allow air to circulate properly on the skin.
  • The feet should be kept as dry as possible, therefore it is recommended to use sandals, cotton socks or shoes that allow the necessary air circulation.
  • During the use of ketoconazole on the hair, the application of colorants, chemicals to straighten or for perms should be avoided.
  • The skin is very delicate, therefore while using this treatment, irritant soaps, depilatory creams, products containing alcohol, astringents or harsh skin cleansers should not be used.
  • Children under 12 years old should not use ketoconazole.

Ketoconazole side effects

Depending on how ketoconazole is used, some disorders or unfavorable effects may arise that affect the body. Among them are:

In case of oral route

  • Sickness.
  • Vomiting
  • Diarrhea.
  • Gastrointestinal, liver and kidney problems.
  • Yellowing of the eyes and skin.
  • Dark coloration in the urine.
  • Lack of appetite or excess fatigue.
  • Pains in the belly and irregularities in the menstrual period.
  • Drowsiness.
  • Dizziness
  • Severe headaches.
  • Inflammation and redness of the eyes.
  • Decreased testosterone production.
  • Sexual impotence in men.
  • Breast enlargement.
  • Azoospermia.
  • Gynecomastia

In case of cream

  • Irritation in certain places.
  • Stinging sensation.
  • Itchy skin
  • Urticaria

In the case of hair shampoo

  • Wounds on the scalp.
  • Crusting.
  • Strong irritations.
  • Hair loss.
  • Oily, bad-smelling or dry scalp.
  • Unfavorable changes in hair texture.

Ketoconazole contraindications

Many people may have problems or risk factors that can affect the body due to the use of ketaconazole, therefore, it could be contraindicated. Here are some of these contraindications:

  • This drug is contraindicated for use in women who are pregnant, it would be very risky for the fetus or during lactation, as it is excreted in breast milk.
  • It is unfavorable in people who have hypersensitivity at the beginning of its use or if they are allergic to any of the components of the formula.
  • Patients who have low acid production or a lower pH in the contents of the stomach system.
  • It is important not to mix ketaconazole with alcoholic beverages, since it could cause the disulfiran effect, which produces fever and various discomforts, therefore it is recommended not to ingest it while under treatment and it should be allowed at least 48 hours after finish it.
  • Ketoconazole is metabolized in the liver in people with hypochlorhydria, this means that the drug does not reach the corresponding plasma levels causing hepatocellular lesions.

Ketoconazole use conclusion

To conclude, it can be said that ketoconazole is a drug that comes in different presentations and acts as an antifungal on the cell walls of fungi to treat the infections and discomfort they produce, such as seborrheic dermatitis, dandruff, ringworm, pityriasis versicolor. , athlete’s feet, cutaneous, vaginal or oral candidiasis, skin mycosis, among others.

We hope this article has the information you were looking for. Thank you for choosing us!

Samantha Robson
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Dr. Samantha Robson ( CRN: 0510146-5) is a nutritionist and website content reviewer related to her area of ​​expertise. With a postgraduate degree in Nutrition from The University of Arizona, she is a specialist in Sports Nutrition from Oxford University and is also a member of the International Society of Sports Nutrition.

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