Januvia is a drug that belongs to the group of dipeptidyl-peptidase 4 inhibitors, which, taken orally, serves to reduce insulin levels, and therefore helps control type 2 diabetes, also called mellitus or not insulin dependent.
Januvia is the name of the medicine whose active substance is sitagliptin, a diabetes drug that increases incretin levels. This is a natural substance that increases the release of insulin to control blood sugar, and that produced by the liver.
Januvia is used to reduce blood sugar levels produced by the body; improves insulin levels after meals. This medicine can be used alone or combined with other sugar-regulating medicines for greater effectiveness in controlling diabetes. Among these, insulin, metformin, sulfonylureas or glitazones; and that in addition, they must be combined with a suitable diet and an exercise program.
What is Januvia for?
Januvia or sitagliptin has many benefits for those with diabetes who consume it, and mixed with a proper diet and exercise program that help control weight and blood sugar, it can be the ideal treatment.
Januvia works especially in people with type 2 diabetes, which in turn can prevent kidney damage; neurological problems; the blindness; sexual function problems; and even loss of limbs, among other conditions and consequences of diabetes.
Januvia is one of the most prescribed drugs for the control of diabetes mellitus. Its mechanism of action consists of inhibiting an enzyme called dipeptidyl peptidase-4 or DPP-4. This in turn slows the inactivation of hormones called incretins that help release insulin into the blood to lower blood sugar levels.
Therefore, the amount of incretin hormones increases and their action is prolonged, which will be released and will increase their response after a meal. Januvia is combined with other antidiabetic drugs in order to have a much more effective action.
Januvia for hypoglycemia
Januvia also has the effect of decreasing glucagon secretion, thanks to pancreatic alpha cells that reduce glucose production in the liver. With this, this drug has the benefit of reducing the side effects produced by hypoglycemine when a blood glucose leveling treatment is being performed.
How is januvia taken?
Januvia should be used under strict medical care and control, and the doctor should recommend the appropriate dose for each patient. It is also very important to read the instructions or label that includes the drug.
Januvia is taken by mouth. Your doctor may recommend that it be done with or without food, and it is usually just one dose per day. The dose will depend on the type of medical condition and how the body responds to drugs, as well as its kidney function. It is important that it is taken regularly and that doses are not missed. In order to remember to take it daily, it is advisable to always take it at the same time each day.
Along with the treatment of januvia, it is recommended to follow a careful diet, following a special diet and also combining it with an active life and an exercise plan. Blood sugar levels should be monitored and the doctor informed so that the doctor can change the treatment dosage when necessary.
The dose of januvia will depend on the type of medical condition and how the body responds to drugs, as well as its kidney function. Generally the usual dose recommended by doctors is one 100 mg tablet once a day by mouth.
The doctor can also prescribe januvia along with other medications that are intended to reduce sugar so that the effect of this is even more effective. Treatment should not be stopped unless instructed by the doctor, it should be taken continuously and the dosage should be changed when the doctor deems it necessary.
The main active ingredient in januvia is sitagliptin, which contains coated tablets made up of 100 mg of sitagliptin phosphate monohydrate.
The other ingredients in this medicine include microcrystalline cellulose (E460), anhydrous calcium hydrogen phosphate (E341), croscarmellose sodium (E468), magnesium stearate (E470b), and sodium stearyl fumarate.
The tablet is film-coated containing polyvinyl alcohol, macrogol 3350, talc (E553b), titanium dioxide (E171), red iron oxide (E172) and yellow iron oxide (E172).
Januvia and Metmorphine
Metmorphine and januvia, or sitagliptin, are often prescribed together for patients with type 2 diabetes to reduce high blood sugar levels, usually in cases where these medications alone are not enough. Both drugs have a very different mechanism of action but with very similar effects.
As previously described, januvia or sitagliptin controls blood sugar levels as it contributes to the release of insulin by increasing hormones and thus reducing the release of glucagon. Metmorphine, for its part, decreases the release and absorption of glucose stored in the liver and contributes to its use by the body, thus lowering sugar levels.
This combination is suitable in patients with type 2, and is not recommended in treatment of insulin-dependent or type 1 diabetes.
In some countries, a Janumet medicine is available, which contains the combination of both active substances metmorphine and sitagliptin in the same tablet at once. This combination of drugs should only be taken by prescription.
Januvia side effects
Many people using Januvia do not have serious side effects. Side effects that can occur with Januvia include nasal congestion, sore throat, headache, back pain, joint or muscle pain, nausea, stomach pain, diarrhea, or constipation.
Januvia itself does not generally cause low blood sugar (hypoglycemia), it could occur if it is prescribed along with other antidiabetic medications. Symptoms of low blood sugar include sudden sweating, shaking, racing heartbeat, hunger, blurred vision, dizziness, or tingling in the hands and / or feet.
Although very rare, there are some serious side effects from Januvia, including pancreatitis (severe pain in the upper stomach spreading to the back); nausea and vomiting; loss of appetite; fast heartbeat – urinating less than normal or not at all; bloating and weight gain.
Special attention should also be paid if there is difficulty breathing; severe skin reaction; fever; throat pain; swelling of the face or tongue; burning eyes; sore skin, followed by a red or purple rash that especially spreads to the face or upper body and causes blistering and peeling.
Additionally, Januvia may interact with digoxin or probenecid, non-steroidal anti-inflammatory drugs (NSAIDs), aspirin or other salicylates, sulfonamides, monoamine oxidase inhibitors (MAOIs), or beta-blockers.
During pregnancy, Januvia should be used only when prescribed. During pregnancy it can cause or worsen diabetes. Your doctor may change your diabetes treatment during pregnancy. Although it is not known if this drug passes into breast milk, caution should be exercised during breastfeeding and should therefore be consulted with a doctor.