Indarzone is a drug belonging to the group of nonsteroidal anti-inflammatory drugs, which is used to treat inflammation, pain and edema. It acts during the active phases of osteoarthritis, deformational spondylitis, rheumatoid arthritis, sprains, spondylitis, bursitis, synovitis, tendonitis, gout and capsulitis. It is also indicated for the prevention of cystic macular edema.

Indarzone dosage for rheumatoid arthritis

Initially the dose used for the treatment of severe rheumatoid arthritis in addition to exacerbations caused by other diseases, is one capsule with intermediate intervals of 8 hours for 1 week, then it will be 1 capsule with intervals of 12 hours between one and the other. for 1 week, then it will be every 24 hours. In the fourth week the capsule will be every 48 hours and for the last week it will be administered every third day until completion.

As the patient shows a satisfactory response, a maintenance dose can be continued, which should be the lowest possible and that provides relief of symptoms, without presenting adverse effects. The duration of the same will vary according to what the treating doctor decides.

How to use Indarzone?

This medicine comes in the following forms: long-acting (slow-release) capsules, oral suspension, suppositories, and regular capsules. In the case of the liquid suspension, suppositories and regular capsules are generally used 2-4 times during the day. Slow-release ones 1 or 2 times a day.

It is suggested to take both the suspension and the regular and slow-release capsules with food, or failing that with antacids or after meals. Try to take it at the same time during the days that the treatment lasts. Do not try to open the slow-release capsules or mix them with drinks or food.

It is important that you shake the suspension with the intention that the medicine mixes evenly. To use the suppositories we recommend the following steps:

  • Remove the wrapper from the suppository and dip the tip of the suppository in water.
  • If you are right-handed, you should lie on your left side and raise your right knee towards your chest. In the case of being left-handed, perform the movement in the opposite way.
  • With the help of your finger, insert it 1 inch into the rectum.
  • You should keep it that way for a few moments.
  • After 15 minutes, you can get up, wash your hands, and continue your routine activities.

Mechanism of action of the Indarzone

After the drug is administered orally to the patient in a dose of 25 mg, it is rapidly absorbed by the body, reaching its maximum concentration in the blood, 1 to 2 mcg / ml for 2 hours after its use. administration. Subsequently, it binds to plasma proteins in a percentage that varies between 90% and 95%, diffusing widely in body fluids and tissues.

After 5 hours of having administered it to the patient, it reaches the same amount of concentration in synovial fluid and plasma. In the central nervous system, breast milk, saliva, placenta, and cerebrospinal fluid are kept at a low concentration. In the liver it is metabolized by conjugation with glucuronic acid and by demethylation.

Elimination from the body occurs through renal excretion in 67% of total elimination. In adults, elimination varies in a range from 2.6 to 11.2 hours. Scientific studies have shown that indomethacin combined with dexamethasone show synergistic effects of additive and supraditive type, both in the case of therapeutic effects and in the limitation of adverse effects.

Indarzone adverse effects

Like any other medicine, this one can cause mild to serious side effects, especially if it is not used under strict medical supervision. Here are some of these effects:

  • Dizziness, vertigo, and headache.
  • Nausea and vomiting
  • Abdominal pain and epigastric discomfort.
  • Irritation and itching.
  • Hemolytic anemia.
  • It can induce anorexia.
  • Nephrotic syndrome.
  • Retinal disorders.
  • Acne and stretch marks.
  • Ringing in the ears
  • Erythema and leukopenia.
  • Asthma.
  • Thrombocytopenia
  • Aguda interstitial nephritis.
  • Irritation of the rectum.
  • Fever.
  • Constant feeling of emptying the intestines.

Precautions

Before starting treatment with this drug, you should take precautions such as: tell your doctor if you are taking any other prescription or non-prescription medications such as nutritional supplements, herbal products, vitamins, among others. If this is the case, manifest any type of allergy especially to indomethacin, naproxen, ibuprofen, aspirin or any non-steroidal anti-inflammatory drug.

In the same way, it is very important to tell your doctor if you are pregnant, breastfeeding or if you have plans to become pregnant. Also if you suffer from asthma, nasal congestion or nasal polyps, depression or mental illnesses, heart failure, liver or kidney disease, Parkinson’s disease or seizures.

In the event that the treatment is with suppositories, you should inform the doctor if you have experienced any inflammation in the rectum or if you have had a rectal bleeding. Talk to your doctor about the collateral damage that the drug could cause in people over 65.

Finally, it is worth mentioning if you will undergo any surgical procedure. The drug causes drowsiness, so you should try not to drive your car or operate heavy machinery. Drinking alcohol can greatly worsen the adverse effects of the drug.

Contraindications

This drug is contraindicated for patients suffering from:

  • Systemic fungal infections
  • Immunosuppression.
  • Mellitus diabetes.
  • Arterial hypertension.
  • Hypersensitivity to indomethacin, dexamethasone, and salicylates.
  • Gastritis erosiva.
  • Renal insufficiency.
  • Peptic ulcer.
  • Tuberculosis.
  • Ocular herpes simplex.
  • Lupus erythematosus.

Indarzone overdose.

It is important that if the patient ingested an overdose of the drug that you go immediately to the hospital. Symptoms of an overdose may be: dizziness, extreme tiredness, upset stomach, seizures, confusion, headache, vomiting, feeling of numbness or prickling of the skin.

conclusion

This drug is basically used for the treatment of inflammatory diseases since its analgesic effect is even greater than that of acetylsalicylic acid. It works by inhibiting cyclooxygenases 1 and 2, which produce the prostaglandins that cause the inflammatory process. Its use must be done under strict medical supervision since its side effects could even be more serious than the disease that the patient is going through.

Samantha Robson
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Dr. Samantha Robson ( CRN: 0510146-5) is a nutritionist and website content reviewer related to her area of ​​expertise. With a postgraduate degree in Nutrition from The University of Arizona, she is a specialist in Sports Nutrition from Oxford University and is also a member of the International Society of Sports Nutrition.

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