Flunarizine is a medicine that is used for the prevention of migraine , it is usually used for preventive control in cases of strong headaches. It is also used as a complement in treatments for epilepsy and balance problems or vertigo.

This medicine is a substance that belongs to the group of calcium blockers, which are known as diphenylpiperazines or as a calcium channel blocker. This group prevents calcium from entering cells.

Benefits of Flunarizine

Thanks to its properties, Flunarizine has great medical benefits, one of the most important is that it can be used for the preventive combat of migraine in severe cases. On the other hand, its use is also recommended in disorders of the circulatory system such as varicose veins.

Flunarizine for the control of migraines

Flunarizine is used to treat severe headaches.

This drug is selective, by physically affecting the calcium entry mechanism through the cell membrane, thus preventing the contraction of smooth muscles and increasing circulation through blood vessels.

It is used preventively when the use of other drugs has not given favorable results in the treatment of these diseases.

Flunarizine to treat vertigo problems

This medicine is used as a reliever with preventive action in dizziness, which has its origin in the accumulation of calcium in the semicircular canals and other ear canals.

In these cases where there are alterations in this system due to circulatory problems or brain diseases, this drug is recommended as a treatment.

Flunarizine for the treatment of patients with epilepsy

Flunarizine serves to reduce the occurrence of seizures in patients diagnosed with epilepsy, as this drug reduces these seizures thanks to its antagonistic effect on calcium channels.

Flunarizine in treatments of diseases of the circulatory system

It is used with very good results on patients with diseases in the blood circulation, which is why it helps in the treatment of disorders of this system, mainly in those that originate from difficulty in the return of blood to the heart and its irrigation to the heart. brain.

Other medical uses of flunarizine

Let’s look at other medical uses this drug has had:

  • It can be used as an antihistamine.
  • Treatment of cold extremities, which can be associated with circulatory problems.
  • It is also used to treat cramps.
  • It is prescribed as part of the treatment of the disorder in the vessels and arteries, whose syndrome is known as Raynaud’s.

Dosage and indications for Flunarizine treatments

Flunarizine is a drug whose use is delicate, the doses vary according to the problem and its severity, it is usually recommended to take it once a day. Only the treating physician can prescribe the treatment according to his professional judgment and according to his specific case.

Flunarizine dosage for treating migraine

The use of this medicine is oral and will be precisely indicated by the doctor accompanying the treatment.

For use, as a migraine preventive, they recommend starting by taking doses of 10 milligrams a day. This amount will be used as a dose to maintain the pharmacological effects against migraine for 5 continuous days and then 2 days off. This treatment should be interrupted after six months and restarted if relapse occurs.It may interest you:

Recommended Flunarizine Dose in Children

For its use in these cases it is advisable to use doses between 2.5 milligrams up to 5. Its taking is recommended at night.

Flunarizine dosage for the treatment of vertigo

Flunarizine will be used in doses of 10 milligrams daily, until the symptoms are controlled. After one or two months, the use of the drug should be discontinued. If symptoms persist, you should contact your doctor.

Recommended dose of flunarizine in the elderly

It is recommended to use an initial dose of five milligrams, administered once a day and preferably taken at night.

Doses that are prescribed should not be exceeded. They need to be monitored regularly, so you should see your doctor. In the case of secondary symptoms such as depression, the doctor will evaluate the suspension of treatment.

What is the mechanism of action of Flunarizine?

The mechanism of action of this drug is given by its antagonistic effect on the absorption of cellular calcium. This acts on the contraction of the vascular smooth muscles, affecting the vasodilation of the arteries, increasing oxygenation to the myocardium. It reduces the pressure of the arteries.

What is the active ingredient in Flunarizine?

This medicine can be found in capsule or tablet forms. Each capsule or tablet of Flunarizine is composed mainly of Flunarizine hydrochloride. The capsules contain it at a rate of 5 milligrams and the tablets at 10 milligrams. Like many other medicines, they contain other excipient ingredients.

Can flunarizine be used to treat hemorrhoids?

This medication is not the first option as part of the treatment of this ailment. You should consult your specialist for your employment.

If I forget to take a dose of flunarizine, what should I do?

If you mistakenly forget to take a dose of flunarizine, you should continue the treatment, without taking the double amount to make up for it.

Side Effects of Flunarizine

During the treatment of diseases with this drug some adverse effects may occur, here are some of those reported by patients:

  • You may feel tired or fatigued.
  • Symptoms of depression may occur.
  • Tremors can occur.
  • Abnormal movements in the face, these occur involuntarily.
  • It can generate an increase in appetite and weight.
  • In children, changes in mood can occur, cause depression and can also cause weight gain.

In fewer cases, patients have reported the following side effects:

  • Insomnia
  • Muscle pains.
  • Stomach pain also known as gastralgia.
  • Anxiety.
  • Sickness.
  • Production of breast milk even when you are not breastfeeding, known as galactorrhea. It can occur in both genders.
  • Rhinitis.
  • Constipation or constipation
  • Pain in the breasts
  • It can affect menstruation.

Contraindications of Flunarazine

The use of this medicine is not recommended if any of the following cases exist:

  • If it is known about sensitivity to its components, which may cause allergies. These symptoms can manifest as:
  • Breathing difficulties asthmatic episodes.
  • Swelling may occur on the face, lips, tongue, and other parts of the body. It is quite serious if it occurs in the vocal cords.
  • It can cause itching known as hives and a skin rash.
  • In more severe cases, loss of consciousness may occur.
  • Presence of paleness and sweating.
  • Stroke due to the presence of a clot.
  • It can cause depression
  • The use of this medicine can cause parkinsonian symptoms, which do not respond to commonly used treatments.

Precautions to consider when taking Flunarizine

Despite its benefits, it is necessary to take into consideration and notify the doctor in case of:

  • Suffering from glaucoma, the use of flunarizine can cause the symptoms to worsen, by increasing the internal pressure of the eye.
  • The use of this medicine can affect urine retention.
  • It can cause liver problems.
  • It generates drowsiness, so it is advisable not to drive or operate heavy machinery.
  • This medicine should not be used together with alcoholic beverages, as the effects are potentiated.
  • Its use is not recommended if you are under treatment with anticonvulsant and antidepressant medications.

In case of pregnancy or lactation period, a doctor should be consulted, even when there is no evidence of the effects of flunarizine on pregnancy, nor its action on the fetus. Likewise, there is no information if this drug is transmitted through milk to the infant.


This medicine was discovered in 1967. It originates from piperazine and has a calming effect, in addition to those already mentioned.

Flunarizine physically acts on the mechanisms that allow calcium to enter cells, which is why it is used in case of migraines and other diseases when there is no improvement with other treatments.

It should be used as a preventive treatment. This medicine acts on the frequency, reducing the times that these ailments usually occur, and to a lesser extent it acts on the intensity or the discomfort that they generate.

Flunarizine manifests its benefits in the treatment of migraine by inhibiting attacks. It works by preventing vasoconstriction that occurs due to lack of oxygen. Its effect is maintained for a long time, that is why it is said to be cumulative and can begin to be observed after several weeks of starting treatment.

For its acquisition and use, the expiration date on the packaging must be verified and, like the rest of the medicines, it must be kept in suitable places at room temperature, without humidity.

Samantha Robson
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Dr. Samantha Robson ( CRN: 0510146-5) is a nutritionist and website content reviewer related to her area of ​​expertise. With a postgraduate degree in Nutrition from The University of Arizona, she is a specialist in Sports Nutrition from Oxford University and is also a member of the International Society of Sports Nutrition.

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