Domperidone is a drug that selectively blocks the receptors that act on some gastrointestinal diseases, in such a way that it is used to treat some common intestinal problems.

It also serves as a propellant and emptying agent for the intestine, so it is a double-acting drug. In this sense, let us emphasize its double action.

Next, we explain the benefits of domperidone, its uses, presentations, recommended doses, contraindications and everything related to this drug.

What is domperidone and what is it for?

The domperidone is a drug belonging to the group of antagonists of dopamine receptors or dopamine, as is also known. This drug efficiently improves intestinal transit, stimulating gastric motility and contributing to the stomach emptying mechanism.

Domperidone is also formulated as an antiemetic, that is, to prevent vomiting or nausea, which is why it is frequently used to treat the disorder known as motion sickness. The drug can be accessed regularly without the need for a medical prescription, however, its use for very long periods is not recommended.

  • It produces a message about the brain, initiating a blocking process in the receptors that are activated by irritations or discomforts related to the intestine, thus reducing the symptoms in the medicated person. Likewise, it acts on the central nervous system reducing vomiting and nausea symptoms.
  • Its second action deals with gastrointestinal motility, regulating the processes involved in the digestion of food, the secretion and absorption of all substances.

Indications for use of Domperidone

Domperidone is generally over-the-counter, however, like any other type of drug, it is advisable to consult a specialist before consuming it. It is indicated to treat the symptoms caused by stomach heaviness that originates from food consumption, abdominal discomfort, flatulence, nausea, vomiting, regurgitation of stomach contents, belching, esophagitis, heartburn and other symptoms produced in the intestine.

Mode of administration and dosage of domperidone

Its administration can be done through the oral or rectal route, it should be done 30–35 minutes before meals for better absorption to occur, it can also be ingested after meals, but the effect will be less because its absorption will be much slower.

It has been determined that domperidone is rapidly absorbed through oral administration on an empty stomach, achieving its maximum effect in a period of 30-60 minutes.

Its presentation is often given in 10 mg tablets or 1 mg oral suspension and the recommended doses vary according to the age of the patient.

Administration of oral domperidone in children older than 12 years

The recommended dose is 2.5 ml for every 10 kilos of weight of the child, three times a day, however, the sum of the daily doses cannot exceed 35 ml. This product should not be administered for more than 7 continuous days.

Administration of oral domperidone in children under 12 years of age

It is recommended for children aged 2 to 12 years, 0.9 ml per kilo for three doses a day before each meal. It should not exceed 2.5 ml daily.

Oral Domperidone Administration in Adults

The recommended dose is 10 ml of syrup or capsules, three times a day for people over 12 years of age and ingested 15 to 30 minutes before each meal for better absorption.

The maximum dose of daily administration can reach 80 ml, however, the side effects presented in the patient will be greater after the suggested 30 ml daily. In this sense, only the doctor should be responsible for deciding and indicating such doses. This product should not be administered for more than 7 continuous days.

Rectal administration of domperidone

  • For adults and children over 12 years of age, one 60 mg suppository three times a day.
  • For children under 12 years of age weighing less than 30 kg, a suppository of 30 mg twice a day.
  • For children under 12 years of age weighing less than 15 kg, a suppository of 30 mg once a day, however, its effectiveness has not been proven.

The use of domperidone for more than a continuous month is not recommended, even if it is the first time you start a treatment, consult your doctor.

Domperidone in drops administration

Each 24 drops or 1 ml contains: 10 mg of domperidone.

  • For infants and children under 6 years the recommended dose is 1 drop / kilo 3 times a day 15 minutes before each meal.

Presentations of domperidone available in the market

  • Containers of 20 capsules.
  • Pediatric suspension, 100 ml container.
  • Drops, 15 ml container.
  • Pediatric suppositories, pack of 5 suppositories of 30mg.
  • Adult suppositories, pack of 5 suppositories of 60 and 30mg.

Side effects of using domperidone

The side effects of donperidone frequently stop when treatment is stopped and do not occur equally in all people who take it. The effects also tend to be mild and reversible.

Among the most common and mild effects are:

  • Headache.
  • Depression.
  • Anxiety.
  • Dry mouth.
  • Urinary retention.
  • Mild abdominal spasms.
  • Diarrhea
  • Constipation.
  • There may also be an increase in the mammary glands (gynecomastia).
  • Alteration in menstruation.
  • Milk secretion.
  • Pain in the breasts

Among the rarer effects are:

  • Severe cardiac arrhythmias.
  • Muscle spasms.
  • Decreased sexual desire
  • Skin rash.
  • Irregular eye movement.
  • Pain in the neck.

Domperidone contraindications

  • It is contraindicated in people who are sensitive or show hypersensitivity to the drug.
  • People suffering from heart disease, cardiac arrhythmias or heart failure.
  • The plasma levels of prolactin generated by the continuous use of the drug are unknown , so its use is not recommended in patients with breast cancer.
  • If you suffer from kidney problems , take special care, ask your doctor about the risk of using the medicine.
  • Gastrointestinal bleeding .
  • If you have liver disorders, consult your specialist beforehand.
  • It is not known if it is safe to use domperidone during pregnancy, therefore, only a specialist doctor should indicate its use.
  • This drug is excreted through breast milk, so it is advisable to use any presentation during breastfeeding, consult your doctor beforehand.
  • Frequent use of this medicine can affect your ability to react and affect your mobility, so it is not recommended to drive transport vehicles or heavy loads.

How should domperidone be taken?

You should take the dose recommended by your doctor and in the interval of time that the treatment has been indicated, the most advisable thing is 15-30 minutes before each meal.

Before taking domperidone note the following:

  • Make a list with all the medications you are consuming and give it to the specialist, if you have doubts, ask all your concerns.
  • Tell your doctor if you suffer from other conditions or if you have recently become ill.

It is recommended that the use of this medication be administered under the supervision of a specialist, however, if you are going to perform a treatment on your own, consider the following:

  • The adverse effects of domperidone can increase if they are combined with the use of other medications, including medicinal plants and any other product that can be purchased without a prescription.
  • You should not take if you are in any treatment for fungal infections, such as ketoconazole.

You should never resart treatment on your own without the prior authorization of your doctor, nor should you recommend the use of the drug to another person, or give up your prescription, even if the symptoms may be similar to yours.

How does domperidone work?

Domperidone is a dopamine antagonist that acts mainly on chemoreceptors (sensory receptors) which convert a chemical signal into an action potential, thus preventing the binding of dopamine to its D2 receptors.

The effects that occur when forcing prevent the union of dopamine with D2 receptors are well known, among them are:

  • Accelerates the passage of food to the stomach.
  • It increases the pressure of the tube that goes from the pharynx to the stomach (esophagus), so it does not allow fluids to return, preventing gastroesophageal reflux.
  • Antiemetic action (reduces vomiting and nausea).
  • Increased prolactin.


The use of domperidone in short periods can alleviate the symptoms caused by nausea and vomiting, as well as can improve intestinal transit and other problems related to the intestine, however, if a treatment was indicated and the discomfort reoccurs at the end of the Likewise, you should not start a new series without consulting your doctor, remember that there may be multiple causes that are causing the discomfort.

Samantha Robson
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Dr. Samantha Robson ( CRN: 0510146-5) is a nutritionist and website content reviewer related to her area of ​​expertise. With a postgraduate degree in Nutrition from The University of Arizona, she is a specialist in Sports Nutrition from Oxford University and is also a member of the International Society of Sports Nutrition.

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