Desloratadine is a drug that belongs to the group of antihistamines, which basically serves to treat allergic conditions such as allergic rhinitis, allergy to dust mites, hives, conditions caused by hay fever, among other conditions whose main symptoms are sneezing, eye irritation (itchy, red or watery), runny nose and stinging palate and nose.

This antiallergic is characterized by being slowly released in our body, that is, it is prolonged release, causing less drowsiness than other drugs of the same type and blocking histamine receptors, the main cause of allergies.

Desloratadine uses

This antihistamine is used to calm a temporary allergy and its accompanying symptoms. It works by reducing the effects caused by our body’s own chemical histamine, which causes itching in the body, a runny nose, sneezing and watery eyes. At the same time it is used to treat patients with hives and chronic skin reactions.

Desloratadine for cough

Although desloratadine is not necessarily indicated for the treatment of cough, it could exert a beneficial effect in the case of cough caused by an allergic condition or allergic cough. In this case, the medicine would act to relieve cough as a symptom of an allergy, but not as a treatment for cough from other causes.

Desloratadine for children

This antiallergic can be used for children from 6 months as long as it is with the supervision of the pediatrician, it is even prescribed for cases of seasonal allergic rhinitis in children 6 to 12 years of age.

How does desloratadine work in the body?

The onset of its action occurs quickly, in approximately half an hour it reaches a high concentration in plasma. Likewise, its action is long-lasting, its half-life time is approximately 27 hours, giving it a wide margin of action.

Indications for administering desloratadine

One of the basic indications when administering any medication, whatever its nature, is precisely to follow the indications given by the treating physician. Generally, this antihistamine is taken only once a day and should not be ingested in smaller or larger amounts than prescribed or for less or longer than recommended.

In the case of regular tablets, they should not be chewed or broken, but should be swallowed whole. As for the liquid presentation, the dose must be measured with a special spoon designed to measure the medicine. It is important to store it away from exposure to heat or moisture, preferably at room temperature.


This drug is administered orally and the dose will always depend on the medical prescription. It should be taken once a day and can be with or without food.

  • For adolescents and adults (12 years and older) the usual dose will be 1 tablet or 5mg tablet or in the case of the syrup 10ml in a single dose.
  • For children it is recommended as follows: from 6 to 11 months 2 ml of syrup, for children from 1 to 5 years 2.5 ml and for children from 6 to 11 years 5 ml. These doses only once a day.


Before ingesting the tablet it is essential to have clean and dry hands to open its packaging. When taking it out, it should be placed on the tongue immediately and swallowed water to swallow it. In the case of the oral disintegrable tablet, follow these recommendations:

  • The tablet should be kept in the wrapper until you are ready to take it, when opening the package and removing it from the folio, try not to push it through it as the tablet could be destroyed.
  • When placed on the tongue, it will begin to dissolve immediately.
  • It should not be swallowed whole but wait for it to dissolve on its own.
  • Swallow saliva several times once the tablet dissolves, if necessary water can be taken.

Presentations of desloratadine

This medicine comes as a regular and disintegrating tablet, oral solution, and syrup. Next, we detail the components according to the presentation:

  • Regular tablets : in addition to containing the active principle (desloratadine) 5mg, it has microcrystalline cellulose, calcium phosphate dihydrate, cornstarch and talc.
  • Disintegrable tablets (2.5 and 5mg): crospovidone, microcrystalline cellulose, colloidal silica dioxide, pregelatinized starch, citric acid, sodium carboxymethyl starch, ferric oxide, magnesium stearate, aspartame (E951), sodium butyl methacrylate copolymer, butyl hydrogen carbonate, mannitol copolymer Tutti-frutti flavor.
  • Oral lyophilisate: includes Polacryllin Potassium, Gelatin, Aspartame (E951), Anhydrous Citric Acid, Mannitol, Hypromellose (E464), Red Ferric Oxide (E172) and Tutti-Frutti Flavor.
  • 0.5mg / ml syrup : also contains citric acid, sodium citrate, propylene glycol, sodium benzoate, sorbitol, sucrose, disodium edetate, natural and artificial aroma, purified water and orange color (E110)

What is the difference between loratadine and desloratadine?

Both belong to the group of antihistamines, that is, they act precisely on histamine, which is the substance that our body releases during allergic conditions. For this reason, these drugs are responsible for blocking H1 receptors directly related to allergic dermatitis, rhinitis and urticaria.

In this sense, one of its main differences is that loratadine has drowsiness as a side effect while desloratadine does not. Another difference is that loratadine is a second generation antiallergic that is generally sold without a prescription and the other antihistamine is third generation derived from the previous one and is required from the medical formula.

In the case of desloratadine it can be administered in patients with asthma, in the case of perennial allergic rhinitis and in fact it can be used in combination with other medications, loratadine is not recommended in these cases.

Who can take desloratadine?

Its use is recommended for both adults and children from 6 months of age, as long as the doctor indicates it. This antiallergic can be administered in patients who experience various types of allergies, such as allergic rhinitis, water and chronic urticaria or any other allergic condition or skin reactions.

Does Desloratadine make you sleepy?

Because it is part of the group of second-generation antihistamines, it is mainly characterized by not causing drowsiness. This is because it does not cross the blood-brain barrier and therefore does not cause impairment in cognitive motor performance.

When taking medications this is one of the questions that arise in patients because there are some antiallergic drugs that tend to gain weight. In this case, there is no such concern because this particular antihistamine belongs to the third generation of the same and its effect on the central nervous system is more specific and less invasive, and therefore does not cause that feeling of hunger and tendency to rise of weight that if they cause the first generation.

Can you drive while taking desloratadine?

This is another doubt that assails patients when they are prescribed an antihistamine because it is commonly known that one of its effects is drowsiness. But this medicine does not produce it, so you can carry out normal activities, even driving, without worry. Only in the extreme case that it causes drowsiness when ingested, should you inform your doctor immediately.

Desloratadine side effects

The administration of this medicine could cause some of the following adverse effects in some patients:

  • Dizziness, headache, extreme tiredness.
  • Throat or muscle pain.
  • Painful menstruation Stomach ache.
  • Feeling of dryness in the mouth
  • In children from 6 to 23 months it could cause fever, diarrhea and insomnia.
  • Exceptionally cases of anaphylaxis were reported.
  • Other symptoms that rarely occur are: seizures, tachycardia, elevated liver enzymes, palpitations, hepatitis, psychomotor hyperactivity, and increased bilirubin.

Precautions to consider

Before starting treatment with this medicine, inform your doctor of any of the following situations, as the case may be:

  • Allergy to loratadine, desloratadine or any other medication.
  • Kidney, liver problems, or phenylketonuria (lack of the enzyme phenylalanine hydroxylase)
  • If you are pregnant, planning to become pregnant, or breast-feeding.
  • If you are taking any other prescription or non-prescription medicine (vitamin complexes, nutritional supplements or any herbal product).

Desloratadine contraindications

It is contraindicated for patients who manifest hypersensitivity to the active principle or to any of its excipients. Likewise, it should be avoided during pregnancy and lactation, not in patients with severe liver failure or a history of allergic conditions to its components.


Being an antihistamine that does not cause drowsiness, it is highly recommended to treat patients with allergic conditions, as long as they do not manifest hypersensitivity to its active ingredient. At the same time, the variety in its presentations facilitates its administration even to children older than 6 months with the respective medical supervision.

Samantha Robson
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Dr. Samantha Robson ( CRN: 0510146-5) is a nutritionist and website content reviewer related to her area of ​​expertise. With a postgraduate degree in Nutrition from The University of Arizona, she is a specialist in Sports Nutrition from Oxford University and is also a member of the International Society of Sports Nutrition.

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