The desloratadine (Clarinex brand name in the US. UU. And Aerius in Europe and Canada) is a tricyclic H1 antihistamine used to treat allergies. It is an active metabolite of loratadine. Desloratadine is used to treat allergic rhinitis and nasal congestion. It is the main metabolite of loratadine and the two drugs are similar in safety and efficacy. Desloratadine is available in many dosage forms and under many brand names throughout the world.

Desloratadine – What is it

Desloratadine is a prescription medicine. It comes in three forms: tablet, disintegrating tablet, and oral syrup. You take all forms by mouth.

Desloratadine is available as the brand-name drug Clarinex. It is also available as a generic drug. An emerging indication for desloratadine is in the treatment of acne, as a low-cost adjunct to isotretinoin and possibly as maintenance therapy or monotherapy.

Desloratadine – Characteristics 

Desloratadine oral tablet is available as a brand name drug and a generic drug. Brand: Clarinex. Desloratadine comes as a tablet, disintegrating tablet, and syrup. You take all forms by mouth. Desloratadine oral tablet is used to treat nasal and non-nasal symptoms of allergic rhinitis.

Desloratadine – Usos

Desloratadine oral tablet is used to treat nasal and non-nasal symptoms of seasonal and perennial allergic rhinitis (allergies). It is also used to help relieve chronic itching caused by hives.

Desloratadine – How it works

Desloratadine is in a class of medications called antihistamines. These are often used to treat similar conditions. This helps to relieve the symptoms of allergic rhinitis. These include sneezing, a runny nose, and red, watery, and itchy eyes.

Desloratadine – Side Effects

Desloratadine oral tablet may cause drowsiness. It can also cause other side effects.

Most common side effects

  • throat pain
  • dry mouth
  • Muscle pain
  • tiredness
  • drowsiness
  • menstrual pain

If these effects are mild, they can go away in a few days to a couple of weeks. If they are more severe or do not go away, talk to your doctor or pharmacist.

Serious side effects

Allergic reaction (hypersensitivity). Symptoms can include:

  • acne
  • itch
  • urticaria
  • swelling of your lips, tongue, face, and throat

Desloratadine – Interactions

Desloratadine oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor must handle all of your medications carefully. Be sure to tell your doctor about all the medications, vitamins, or herbs you are taking.

Examples of medications that can cause interactions with desloratadine are listed below.

Anti-infective drugs

Examples of these medications include:

  • ketoconazole
  • erythromycin
  • azithromycin

Cholesterol drugs

When taken with desloratadine, some cholesterol medications can increase the amount of desloratadine in your body. This can cause more side effects. Examples of these medications include:

  • atorvastatin

Medications against HIV infection and hepatitis C virus (HCV)

When taken with desloratadine, some HIV and HCV medications can increase the amount of desloratadine in your body. This can cause more side effects. Examples of these medications include:

  • ledipasvir
  • lopinavir
  • ombitasvir
  • paritaprevir
  • ritonavir
  • saquinavir

Heart rhythm drugs

When taken with desloratadine, some heart rhythm medications can increase the amount of desloratadine in your body. This can cause more side effects. Examples of these medications include:

  • dronedarona

Cancer drugs

When taken with desloratadine, some anticancer drugs can increase the amount of desloratadine in your body. This can cause more side effects. Examples of these medications include:

  • tacrolimus
  • tamoxifen
  • sunitinib
  • vandetanib
  • vemurafenib
  • lapatinib
  • fluoxetine

When taken with desloratadine, fluoxetine can increase the amount of desloratadine in your body. This can cause more side effects. Ask your doctor if this medicine is safe for you.

Desloratadine – Precautions

Allergy warning: you should not use desloratadine if you are allergic to it or any of its ingredients. This medicine can cause a hypersensitivity (allergic) reaction. This can cause itching, rash, swelling, shortness of breath, and swelling of the lips, face, or tongue.

Warnings for other groups

For pregnant women: Desloratadine is a category C pregnancy drug. That means two things:

Research in animals has shown adverse effects to the fetus when the mother takes the drug.
Not enough human studies have been done to be sure how the drug might affect the fetus.
Talk to your doctor if you are pregnant or planning to become pregnant. This drug should be used only if the potential benefit justifies the potential risk.

If you become pregnant while taking this medicine, call your doctor immediately. For women who are breastfeeding: Desloratadine passes into breast milk and may cause side effects in a child who is breastfed. Talk to your doctor if you breastfeed your child. You may need to decide whether to stop breast-feeding or to stop taking this medicine.

For Seniors: Older adults may process drugs more slowly. A typical adult dose can cause levels of the drug to be higher than normal in your body.

For children: This medicine has not been shown to be safe and effective in children younger than 6 months. It should not be used in children younger than 6 months.

Desloratadina – Administration

All possible dosages and drug forms may not be listed here. Your dosage, medicine form, and how often you take the medicine will depend on:

  • your age
  • the condition being treated
  • how serious is your condition
  • other medical conditions you have
  • how do you react to the first dose

Form: oral tablet
Strength: 5 mg
Form: oral disintegrating tablet
Strengths: 2.5 mg, 5 mg
Brand: Clarinex

Form: oral tablet
Strength: 5 mg
Brand: Clarinex

Form: orally disintegrating tablet
Strengths: 2.5 mg, 5 mg
Dosage for seasonal allergic rhinitis
Adult dosage (over 18 years)

Typical dosage for both tablets: one 5 mg tablet once a day.
Child dosage (12 to 17 years old)

Typical dosage for both tablets: one 5 mg tablet once a day.
Child dosage (6 months to 11 years)

Typical dosage for disintegrating tablets:
Ages 6 to 11 years: One 2.5 mg tablet once daily.
6 months to 5 years: This form has not been confirmed to be safe and effective for this age group.
Other Ways: Children 6 months to 11 years are recommended to use the oral syrup instead of the oral tablet.
Child dosage (0-5 months)

This medicine has not been shown to be safe and effective in children younger than 6 months. It should not be used in children younger than 6 months.

Dosage for perennial allergic rhinitis
Adult dosage (over 18 years)

Typical dosage for both tablets: one 5 mg tablet once a day.
Child dosage (12 to 17 years old)

Typical dosage for both tablets: one 5 mg tablet once a day.
Child dosage (6 months to 11 years)

Samantha Robson
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Dr. Samantha Robson ( CRN: 0510146-5) is a nutritionist and website content reviewer related to her area of ​​expertise. With a postgraduate degree in Nutrition from The University of Arizona, she is a specialist in Sports Nutrition from Oxford University and is also a member of the International Society of Sports Nutrition.

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