The 625mg Curam is a composition of a high-spectrum antibiotic such as amoxicillin and an inhibitor such as clavulanic acid, which serves to attack infections created by bacteria that are canceled thanks to this powerful combination.
This formula is indicated to fight different types of infections, such as those created in the kidneys and bladder, in the subcutaneous and superficial layers of the skin, some less common such as pneumonia or acute bronchitis in the chest, ear infections or nasal, among others.
We invite you to continue with the article to learn more about its uses, composition and side effects.
Index
What is Curam 625mg for?
This fusion of ingredients mainly attacks those bacteria that cause infections, through an oral therapeutic treatment indicated by a doctor. Among the most frequent conditions are:
- Postoperative infections.
- Infections of the urinary tract and pelvic area.
- Skin infections and soft tissue tissues: Boils / abscesses, cellulitis, wound infections and intra-abdominal sepsis.
- Upper respiratory tract infections, including ENT: Sinusitis, tonsillitis, and otitis media.
- Lower respiratory tract infections: acute and chronic bronchitis, pneumonia and lung abscesses.
- Soft chancre or chancroid caused by the bacterium Haemophilus ducreyi , responsible for this sexually transmitted disease characterized by painful sores or chancres on the genitals.
What is Curam 625mg?
This drug is an excellent compound that integrates two powerful active ingredients, amoxicillin as the main antibiotic and clavulanic acid that acts as a great inhibitor, together achieving an action on the bacteria and inhibiting the synthesis of the cell wall in it, which achieves in the growth stage, competitively disabling and canceling its transpeptidases, which is the enzyme necessary for its formation.
Mechanism of action of Curam 625mg
This mechanism of action is based on the union of beta-lactamases and clavulanic acid, which, despite having a very weak antibacterial activity, when united with the other component is irreversible and thus inhibits the destruction of amoxicillin.
The elimination process of these drugs occurs through the urinary tract in a constant and practically unalterable manner, once its oral dose is administered, in approximately one hour.
Feeding in parallel with the taking of the drug, either before or after, does not alter its absorption, since it is poorly absorbed in the body, although it is transmitted through the placenta sparingly and in very few amounts through milk. maternal, which does not indicate that it is harmful.
The antibacterial spectrum of this drug includes certain clinically recognized microorganisms, although many are resistant or partially resistant to it, among which we can mention are:
- Pseudomonas aeruginosa.
- Staphylococci.
- Mycoplasma.
- Chlamydiae.
- Haemophilus influenzae.
- Streptococci.
- Enterococci.
- Escherichia coli.
- Salmonellae.
- Proteus vulgaris.
- Klebsiella pneumoniae.
Formula and composition of Curam 625mg
Each tablet of this medicine contains on the one hand 500mg of amoxicillin present as amoxicillin trihydrate and 125mg clavulanic acid present as potassium clavulanate, plus excipients.
In addition to these components, you can find non-active ingredients such as:
- Talcum powder.
- Magnesium stearate.
- Methyl alcohol.
- Titanium dioxide.
- Silicone dioxide.
- Povidona.
- Croscarmeose sodium.
- Hydroxypropylcellulose.
- Polyethylene glycol 8000.
- Sodium starch glycolate.
Recommended dose
This class of medicine is used in the patient according to his age and the disease to be treated, to avoid adverse effects or an overdose. It can be classified as follows:
Dosage in adults and adolescents:
In cases of soft chancre, administer 500 mg of amoxicillin and 125 mg of clavulanic acid every 8 hours for 3 to 7 days, according to medical recommendation.
To combat severe respiratory infections, 500 mg of amoxicillin and 125 mg of clavulanic acid are also administered every 8 hours.
If there are other infections, 500 mg of amoxicillin and 125 mg of clavulanic acid every 12 hours are enough, as long as the specialist so indicates.
Pediatric dosage:
In the case of minors, it is advisable to use the presentation of Curam forte of 156.25mg / 5ml, which comes in powder for oral suspension, this if the infant or child to be treated weighs less than 40 kg, in case of If it is more than 40kg, the treatment will be applied as a teenager or adult, mentioned above.
In any of the cases, it is not recommended that it be administered for more than 15 days, without proper monitoring of the evolution of the disease, in case there is no improvement in that time, you should see a doctor immediately and do not extend the treatment on your own.
Commercial presentation
This medicine will be available for sale to the public in boxes or packages of 14 tablets of 625mg each. For minors it will be presented as a powder for oral suspension of 156.25mg / 5ml.
Contraindications
There is a risk of anaphylaxis or hypersensitivity to penicillin or any of the active ingredients such as beta-lactamase, manifesting a serious immediate reaction due to the influence of the drugs.
Allergic reactions can appear as follows:
- Difficulty breathing.
- Asthma.
- Arrhythmia.
- Swelling of the face, especially the tongue, lips, and eyes.
- Acne.
- Discoloration in the affected area.
- Loss of consciousness
- Excessive sweating
- Pallor.
No dose should be administered, without first consulting in patients with liver dysfunction, lymphatic leukemia, active gastrointestinal renal dysfunction and allergic to the components of the drug or any of its derivatives, as they would immediately respond negatively to the components fused in these tablets.
On the other hand, it is alerted in pediatric cases that neonates’ renal function is incompletely developed and the renal elimination of penicillins may become complex for their body, delaying their excretion. Aggression and irritability reactions have also been found in children due to this drug.
Penicillin is a component of this drug that can develop oral candidiasis, take precautions against prolonged use of this drug.
This product has been supplied in pregnant women in limited cases and it is recommended not to use it, especially in the first trimester, unless your specialist deems it necessary. This drug crosses the placenta and in the lactation period, traces of amoxicillin can be detected in breast milk.
Side effects of Curam 625mg
Among the most frequent adverse reactions we can mention:
- Diarrhea.
- He retched.
- Diaperitis or contact dermatitis.
- Changes in behavior (more evident in pediatric patients).
- General discomfort.
- Liver dysfunction
- Seizures
- Pain in the thoracic area.
- Colitis.
Interaction with other drugs or components
The simultaneous administration of antacids reduces the absorption of amoxicillin, alcohol consumption should also be avoided during and a few days after treatment. Taking allopurinol during amoxicillin therapy may promote the incidence of skin reactions, but the cause is still unknown.
On the other hand, it should not be administered simultaneously with chloramphenicol, erythromycines, sulfonamides or tetracyclines, as well as other antibiotics such as aminopenicillins, since both these and amoxicillin can nullify or reduce the effect of oral contraceptives.
Share this information if it has been useful for you, also telling us what your experience has been with this medicine.
Dr. Samantha Robson ( CRN: 0510146-5) is a nutritionist and website content reviewer related to her area of expertise. With a postgraduate degree in Nutrition from The University of Arizona, she is a specialist in Sports Nutrition from Oxford University and is also a member of the International Society of Sports Nutrition.
