The Clarityne D is an antihistamine drug that acts on the body as an antiallergic, used to relieve symptoms of nasal congestion and symptoms associated with allergic rhinitis, sneezing, watery eyes, runny nose, itching or different types of immune reactions the body to different types of external agents and that their reaction is produced by consumption, inhalation or physical contact with it.

Its action is long-lasting so it much better facilitates its dosage on the patient, it is usually recommended to alleviate and treat the symptoms caused by hay fever, allergies to dust, mites, pets and other effects caused by different allergenic agents. that trigger nasal congestion, tearing and irritation in the eyes, itchy throat or nose, sneezing and itchy skin.

In the next post we will highlight a little better the uses that are given to this drug, as well as its effects and indications, we will mention that you must take into account before consuming it and what precautions you must consider for effective use, among many other things.

Clarityne d indications

It is used to treat:

  • Symptoms caused by hay fever (allergy to plants), pet dander, dust mites, among others.
  • Symptoms produced by seasonal or perennial allergy, the most frequent symptoms are: runny and runny nose, tear discharge, redness and itching of the nose, eyes and throat.
  • Relieves hives produced by the body’s autoimmune system in reaction to some external agents.
  • It is indicated when you want to have the antihistamine effect of loratadine and the decongestant effect that pseudoephedrine sulfate provides on the patient’s body.

Mechanism of action (loratadine + pseudoephedrine)

Loratadine is considered a long-acting H1 receptor antagonist, it inhibits the production of the hormone produced by histamine (a substance that is produced when an allergic reaction occurs in the body), reducing or eliminating the effects it produces and thus blocking its neurotransmitter capacity.

Pseudoephedrine, for its part, is a drug that has an adrenergic agonist action that exerts effects similar to those of epinephrine (adrenaline), in this sense it activates alpha adrenergic receptors, thus producing vasoconstriction in the upper respiratory tract, producing an effect of nasal decongestion increasing nasal secretions and opening the tubes of the tuba or auditory tube.


The active principle is loratadine and phenylephrine hydrochloride, according to its presentation it is formulated:

Each tablet contains:

  • Loratadina 5 mg.
  • Phenylephrine hydrochloride 30 mg.
  • Excipient or vehicle cbp 1 tablet.

Children’s solution, each 1 ml contains:

  • Loratadina 0,5 mg.
  • Phenylephrine hydrochloride 6 mg.
  • Vehículo cbp 1 ml.

Pediatric drop solution, each 1 ml contains:

  • Loratadina 1 mg.
  • Phenylephrine hydrochloride 7.5 mg.
  • Vehículo cbp 1 ml.

What you should know before consuming this medicine

  • You should never supply more than the recommended dose in a 24-hour period, if the product is long-acting for 12 hours, consume two tablets a day and if it is long-acting for 24 hours, only consume one daily dose.
  • Consult with your doctor before using the product with another medication, since they may have the same active products, which can cause an accidental overdose and considerably increase the chances of suffering adverse effects.

If you are consuming combined cough and cold medications, read carefully the formula and content of the pampering, pseudoephedrine can cause death in young children or even have serious effects on their health.

If you are going to undergo a study or some type of allergic test, you should inform your doctor beforehand that you are taking this drug, since this drug has been shown to significantly alter the results.

It is not valued by the Food and Drug Administration (FDA) and they have not issued an informative bulletin on the possible harm that may occur to the fetus due to its consumption during pregnancy, so the use of it is not recommended, consult with your specialist doctor before doing so.

The drug passes to the baby through breast milk and its use in lactation is contraindicated.

Side effects

The use of any drug can produce unwanted effects in the body due to its response to the effects of an external agent, not all individuals have the same reactions to a product, however, here we will leave you a list with the effects best known:

Common effects (probably 1 in 10 people)

  • Fatigue.
  • Headache.
  • Sickness.
  • Dry mouth.
  • Drowsiness.
  • Dizziness.
  • Gastritis.
  • Soft spot.
  • Acne.

Uncommon effects (probably 1 in 100 people)

  • Alopecia.
  • Anaphylaxis.
  • Extreme fatigue
  • Liver disorders
  • Skin rash.
  • Difficulty to sleep.
  • Agitation.
  • Abdominal pain.
  • Nervousness.

Uncommon effects (probably 1 in 1,000 people)

  • Severe allergic reactions
  • Difficulty breathing.
  • Hallucinations
  • Hypotension
  • Cardiovascular collapse
  • Fast heartbeat
  • Urticaria.
  • Asthenia.
  • Gastric irritation.
  • Confusion and disorientation.
  • Seizures
  • Aggressiveness.
  • Abnormal liver function
  • Tachycardia.
  • Swelling in different parts of the body.

Very rare effects (probably 1 in 10,000 people)

  • Difficulty or loss of control in urine.
  • Fluid retention and difficulty urinating
  • Spontaneous spasms
  • Pallor
  • Depression of the central nervous system.
  • Blurry vision.


If you are sensitive to any of its active components, adrenergics or substances that contain a similar chemical structure.

If you suffer from some recognized pathologies such as:

  • Narrow-angle glaucoma.
  • Severe hypertension
  • Severe coronary artery disease.
  • Urinary retention.
  • Peptic ulcer.
  • Asthma.
  • Mellitus diabetes.
  • In patients who are under treatment of MAO inhibitors.

The FDA has not evaluated the drug, so there is no safety for use during pregnancy, the specialist doctor must decide if the benefit to the mother justifies the risk that the fetus may run during its use.

During the lactation period, the drug should not be given, since it is eliminated through breast milk and can cause harm to the baby.

Interactions with other medications and other sources.

Medicines used to treat:

  • Yeast infections
  • Antibiotics to treat bacterial infections such as (erythromycin).
  • Antihypertensives.
  • MAOI inhibitors. (antidepressants)
  • Drugs that inhibit or are metabolized through liver enzymes.
  • Beta-adrenergic blocking agents

Some antacids increase the absorption rate of pseudoephedrine, whereas kaolin and pectin decrease it.

Do not drink alcohol while using the drug, as studies have shown that the effects of its components lose their action and potency when combined with it.

General precautions

  • It is recommended to use with caution in patients suffering from glaucoma, increased intraocular pressure, peptic ulcer, prostatic hypertrophy, pyloroduodenal obstruction, cardiovascular disease, diabetes mellitus.
  • The pill form should not be used in children under 12 years of age.
  • The syrup infant solution should not be used in children under 2 years of age.
  • The pediatric drop solution should not be used in children under 1 year of age.
  • Sympathomimetic agents can stimulate the central nervous system, leading to seizures, cardiovascular collapse, hypotension, and excitement.
  • Although negative effects on the ability to drive heavy machinery and motor vehicles have not been considered, it is recommended not to do so since among the side effects it can cause drowsiness.
  • Alcohol or psychotropic substances should not be consumed while taking the drug.
  • Always keep a list of medications, vitamins, dietary supplements and any other medications that you consume, whether they are prescribed or that do not require a prescription, check with your doctor before self-medicating.

Storage and preservation

  • Always keep the product in its original packaging, closed and out of the reach of children.
  • Never store the product in humid places such as bathrooms, or expose it to the sun’s rays or high temperatures, try to keep it below 30 ° C.
  • If more than six months have passed after using the product for the first time, discard the presentation and do not ingest it.
  • After three months of the expiration date of the drug, it should not be consumed.
  • Never dispose of medicines by throwing them in the trash, it can cause accidental consumption by children and pets. Do not flush down the drain or flush down the toilet, ask your nearest pharmacist for the medication waste plan.

In the event of an accidental overdose

In case of an overdose you should receive treatment immediately, go to the nearest health center for medical attention. If the person is collapsed and has difficulty breathing or seizures, call the emergency service for assistance.

Some manifestations of overdose are usually:

  • Central nervous system depression (cardiovascular collapse, sedation, cyanosis, apnea, alertness).
  • Central nervous system stimulation (drowsiness, tremors, hallucinations, seizures, and even death may occur).
  • Other more common symptoms can be: excitement, rapid heartbeat, euphoria, nausea, dry mouth, thirst, sweating, dizziness, ataxia, blurred vision.

We hope that the information provided has been very useful to you, remember that you never seek to supplant medical opinion or criteria, so we recommend that you visit a health professional for an accurate diagnosis before starting its use, especially if you are in treatment with other medications. Thanks for reading!

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Dr. Samantha Robson ( CRN: 0510146-5) is a nutritionist and website content reviewer related to her area of ​​expertise. With a postgraduate degree in Nutrition from The University of Arizona, she is a specialist in Sports Nutrition from Oxford University and is also a member of the International Society of Sports Nutrition.

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