The aspirin , also known as acetylsalicylic acid (ASA) or agin , is a drug used to treat pain, fever or inflammation. Specific inflammatory conditions in which aspirin is used include Kawasaki disease, pericarditis, and rheumatic fever.

Aspirin is used long-term to help prevent heart attacks, ischemic strokes, and blood clots in people at high risk.

It can also lower the risk of certain types of cancer, particularly colorectal cancer. For pain or fever, the effects generally begin within 30 minutes.

Agin – What is it

Aspirin is a non-steroidal anti-inflammatory drug (NSAID) and works in a similar way to other NSAIDs, but it also suppresses the normal function of platelets.

Agin – Pharmacological action

Agin is an NSAID. It has an anti-inflammatory, analgesic and antipyretic effect, and inhibits platelet aggregation. The mechanism of action is associated with inhibition of the activity of COX, the main enzymatic metabolism of arachidonic acid, which is a precursor to prostaglandins that play an important role in the pathogenesis of inflammation, pain, and fever.

The reduction of prostaglandins (mainly E1) in the thermoregulation center leads to a decrease in body temperature due to the expansion of blood vessels in the skin and increased perspiration. The analgesic effect of Agin (Aspirin) is due to the central and peripheral effects. Reduces aggregation, platelet adhesion, and thrombus formation through suppression of platelet thromboxane A2 synthesis.

It is effective in the primary prevention of the cardiovascular system and the secondary prevention of myocardial infarction. At a daily dose of 6g or more, it inhibits prothrombin synthesis in the liver and increases prothrombin time.

Agin (Aspirin) increases the fibrinolytic activity of plasma and reduces the concentration of coagulation factors dependent on vitamin K (II, VII, IX, X). Increases the rate of bleeding complications in performing surgical procedures, increases the risk of bleeding during anticoagulant treatment. It stimulates the excretion of uric acid (which violates its reabsorption in the renal tubules) but in high doses.

Agin – Pharmacokinetics

When administered orally, Agin (Aspirin) is rapidly absorbed primarily from the proximal small intestine and to a lesser extent from the stomach. The presence of food in the stomach significantly affects the absorption of Agin (Aspirin). Metabolized in the liver by hydrolysis with the formation of salicylic acid with subsequent conjugation with glycine or two drugs.

The concentration of salicylates in blood plasma is variable. About 80% of salicylic acid is bound to plasma proteins. Salicylates readily penetrate many body tissues and fluids, including cerebrospinal, peritoneal, and synovial fluid. In small amounts, salicylates are found in brain tissue, fingerprints, in bile, sweat, and feces.

Penetration into the joint cavity is accelerated in the presence of hyperemia and edema, and is slowed in the proliferative phase of inflammation. If you have acidosis, most of the salicylate turns into agglomerated acid, a good penetration into tissue, even into the brain.

Agin (Aspirin) is removed mainly by active secretion in the tubules of the kidneys in unchanged form (60%) and in the form of metabolites. The removal of unchanged salicylate depends on the pH of the urine (alkalinization of the urine increases ionized salicylates, worsens their reabsorption, and increases excretion). T1 / 2 of Agin (aspirin) is approximately 15 minutes. T1 / 2 of salicylate in a low dose reception is 2-3 h, with an increase in the dose can increase to 15-30 hours. Salicylate elimination in newborns is much slower than in adults. ad.

Agin – What is it for

Rheumatism, rheumatoid arthritis, infectious-allergic myocarditis, fever during infectious and inflammatory diseases, pain syndrome, weak and medium intensity of various origins (including neuralgia, myalgia, headache); prevention based on thrombosis and embolism, primary and secondary prevention of myocardial infarction, prevention of violations of cerebral circulation by ischemic type.

In clinical immunology and allergy: Gradually increasing doses for prolonged desensitization of “aspirin” and the formation of stable tolerance to NSAIDs in patients with “aspirin asthma” and “aspirin triad”.

Agin – Individual Dosage and Administration

For oral administration, the dosage of the Agin regimen depends on the indication for use. The usual adult dose when used as an antipyretic and analgesic is 500-1000 mg / day (up to 3 g) and they were divided into 3 admissions. In myocardial infarction, as well as for secondary prevention in patients after myocardial infarction: 40-325 mg once a day (usually 160 mg). As an inhibitor of platelet aggregation: a dose of 300-325 mg / day, for a long time. In dynamic circulatory disorders in men, cerebral thromboembolism, including to prevent a recurrence – 325 mg / day with gradual increase to a maximum of 1 g / day.

For prevention of aortic shunt thrombosis or occlusion: 325 mg every 7 h after intranasal gastric tube placement, then by mouth up to 325 mg 3 times daily (usually in combination with dipyridamole, which was removed after 1 week, continuing long-term treatment with Agin (Aspirin).

Agin – Side Effects

  • Digestive system: nausea, vomiting, anorexia, epigastric pain, diarrhea; rarely – the appearance of erosive and ulcerative lesions, bleeding from the gastrointestinal tract, abnormal liver function.
  • Central nervous system: long-term use can be dizziness, headache, reversible visual disturbances, tinnitus, aseptic meningitis.
  • Hemopoietic system: rarely – thrombocytopenia, anemia.
  • Blood coagulation system: rarely – hemorrhagic syndrome, prolonged bleeding time.
  • Urinary system: rarely – renal dysfunction, with prolonged use – acute renal failure, nephrotic syndrome.
  • Allergic reactions: rarely – rash, Quincke’s edema, bronchospasm, “aspirin triad” (a combination of bronchial asthma, recurrent nasal polyposis and paranasal sinuses and intolerance to Agin (Aspirin) and pyrazolone drug series).

Agin – Contraindications

Phase of exacerbation of erosive ulcerative lesions in the gastrointestinal tract, gastrointestinal bleeding, “aspirin triad”, history of urticaria, rhinitis caused by taking Agin (Aspirin) and other NSAIDs, hemophilia, hemorrhagic diathesis, gipoprothrombinemii, dissecting aortic aneurysm, portal hypertension, vitamin K deficiency, liver and / or kidney failure, glucose-6-phosphate dehydrogenase deficiency, Reye’s syndrome, age of children (under 15 years): risk of developing Reye’s syndrome in children with hyperthermia in a history of viral diseases), I and III trimesters of pregnancy, lactation, hypersensitivity to Agin (Aspirin) and other salicylates.

Use during pregnancy and lactation Agin (acetylsalicylic acid) is contraindicated in trimesters I and III of pregnancy. In the II trimester of pregnancy can a single reception in strict condition. This drug has a teratogenic effect: when used in the I trimester it leads to upper palatoschisis, in the third trimester – it causes inhibition of labor (inhibition of prostaglandin synthesis), premature closure of the ductus arteriosus in the fetus, hyperplasia pulmonary vascular and hypertension in the pulmonary circulation. Agin (Aspirin) (acetylsalicylic acid) is excreted in breast milk, increasing the risk of bleeding in a child due to platelet dysfunction and therefore should not be applied.

Samantha Robson
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Dr. Samantha Robson ( CRN: 0510146-5) is a nutritionist and website content reviewer related to her area of ​​expertise. With a postgraduate degree in Nutrition from The University of Arizona, she is a specialist in Sports Nutrition from Oxford University and is also a member of the International Society of Sports Nutrition.

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